Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGFRL1 | Q5TC84 | 20/20 | 0.82 |
| ▸ | OPRM1 | P35372 | 15/20 | 0.70 |
| ▸ | OPRK1 | P41145 | 13/20 | 0.70 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL880614 | 0.90 | OGFRL1 (1.00) | OGFRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL17874952 | 0.84 | OGFRL1 (0.75) | OGFRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL880327 | 0.83 | OGFRL1 (1.00) | OGFRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL880591 | 0.81 | OGFRL1 (1.00) | OGFRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL880811 | 0.80 | OGFRL1 (1.00) | OGFRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL853021 | 0.80 | OGFRL1 (0.89) | OGFRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL854214 | 0.80 | OGFRL1 (1.00) | OGFRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL880607 | 0.80 | OGFRL1 (1.00) | OGFRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL21548032 | 0.80 | OGFRL1 (0.77) | OGFRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL17561623 | 0.78 | OGFRL1 (0.83) | OGFRL1OPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9527840-B2 | Substituted-quinoxaline-type piperidine compounds and the uses thereof | PURDUE PHARMA L.P. (US) | 2016-12-27 | — | — | US | disclosed |
| EP-3101018-A1 | SUBSTITUTED-QUINOXALINE-TYPE-PIPERIDINE COMPOUNDS AND THE USES THEREOF | Purdue Pharma L.P. (US) | 2016-12-07 | — | — | EP | disclosed |
| US-20160159785-A1 | SUBSTITUTED-QUINOXALINE-TYPE PIPERIDINE COMPOUNDS AND THE USES THEREOF | PURDUE PHARMA L.P. | 2016-06-09 | — | — | US | disclosed |
| US-9278967-B2 | Substituted-quinoxaline-type piperidine compounds and the uses thereof | PURDUE PHARMA L.P. (US) | 2016-03-08 | — | — | US | disclosed |
| US-20150141643-A1 | SUBSTITUTED-QUINOXALINE-TYPE PIPERIDINE COMPOUNDS AND THE USES THEREOF | PURDUE PHARMA L.P. | 2015-05-21 | — | — | US | disclosed |
| US-20100216726-A1 | Substituted-Quinoxaline-Type Piperidine Compounds and the Uses Thereof | PURDUE PHARMA L.P. (US) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160159785-A1 | SUBSTITUTED-QUINOXALINE-TYPE PIPERIDINE COMPOUNDS AND THE USES THEREOF | P2RX4, P2RX5, P2RX3 | OGFRL1 2120/4885OPRM1 25/4885OPRK1 6/4885 |
| US-20100216726-A1 | Substituted-Quinoxaline-Type Piperidine Compounds and the Uses Thereof | P2RX4, P2RX5, P2RX3 | OGFRL1 2120/4885OPRM1 25/4885OPRK1 6/4885 |
| US-20150141643-A1 | SUBSTITUTED-QUINOXALINE-TYPE PIPERIDINE COMPOUNDS AND THE USES THEREOF | P2RX4, P2RX5, P2RX3 | OGFRL1 2120/4885OPRM1 25/4885OPRK1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.