Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 4/20 | 0.53 |
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL63658 | 0.83 | OPRD1 (0.56) | OPRD1OPRM1DRD2SLC18A3ALDH1A1 | |
| SCHEMBL175904 | 0.81 | SLC18A3 (0.57) | SIGMAR1DRD2SLC18A3KMT2A | |
| SCHEMBL1305666 | 0.80 | ESRRG (0.50) | LTA4HSIGMAR1DRD2SLC18A3 | |
| SCHEMBL4200544 | 0.80 | CYP2C9 (0.45) | OPRD1OPRM1DRD2ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL4200491 | 0.79 | GAA (0.44) | SIGMAR1DRD2ALDH1A1LMNAGAA | |
| Hydrochloric Acid SCHEMBL5353922 | 0.79 | ESRRG (0.52) | LTA4HSIGMAR1DRD2SLC18A3ALDH1A1 | |
| SCHEMBL82136 | 0.78 | SLC18A3 (0.45) | DRD2SLC18A3 | |
| SCHEMBL1306432 | 0.78 | DRD2 (0.67) | SIGMAR1DRD2SLC18A3ALDH1A1 | |
| SCHEMBL28176910 | 0.78 | SLC18A3 (0.48) | LTA4HSIGMAR1DRD2SLC18A3ICAM1 | |
| SCHEMBL17290044 | 0.77 | SLC18A3 (0.50) | LTA4HSIGMAR1DRD2SLC18A3ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044075-B1 | FURO [3, 2-B] PYRROL DERIVATIVES | AMURA THERAPEUTICS LTD (GB) | 2013-01-02 | — | — | EP | disclosed |
| EP-2046796-B1 | TETRAHYDROFURO [3, 2 -B]PYRR0L-3-ONES AS CATHEPSIN K INHIBITORS | AMURA THERAPEUTICS LTD (GB) | 2012-10-24 | — | — | EP | disclosed |
| EP-2046795-B1 | FURO[3,2-B]PYRROL-3-ONE DERIVATIVES AND THEIR USE AS CYSTEINYL PROTEINASE INHIBITORS | AMURA THERAPEUTICS LTD (GB) | 2012-10-17 | — | — | EP | disclosed |
| EP-2081919-B1 | TETRAHYDROFURO [3, 2-B]PYRR0L-3-0NE INTERMEDIATES | AMURA THERAPEUTICS LTD (GB) | 2012-05-23 | — | — | EP | disclosed |
| EP-2046798-B1 | FURO [3,2-B]PYRROL-3-ONE DERIVATIVES AND THEIR USE AS CYSTEINYL PROTEINASE INHIBITORS | AMURA THERAPEUTICS LTD (GB) | 2012-05-16 | — | — | EP | disclosed |
| US-8053437-B2 | Furo[3. 2-B] pyrrol derivatives | AMURA THERAPEUTICS LIMITED (GB) | 2011-11-08 | — | — | US | disclosed |
| US-8039641-B2 | Tetrahydrofuro[3,2-b] pyrrol-3-one intermediates | AMURA THERAPEUTICS LIMITED (GB) | 2011-10-18 | — | — | US | disclosed |
| US-7846934-B2 | Furo[3,2-B] pyrrol-3-one derivatives and their use as cysteinyl proteinase inhibitors | AMURA THERAPEUTICS LIMITED (GB) | 2010-12-07 | — | — | US | disclosed |
| US-7846935-B2 | Furo[3,2-B]pyrrol-3-one derivatives and their use as cysteinyl proteinase inhibitors | AMURA THERAPEUTICS LIMITED (GB) | 2010-12-07 | — | — | US | disclosed |
| US-7803803-B2 | Tetrahydrofuro[3,2-B] pyrrol-3-ones as cathepsin K inhibitors | AMURA THERAPEUTICS LIMITED (GB) | 2010-09-28 | — | — | US | disclosed |
| EP-2046796-A1 | TETRAHYDROFURO [3, 2 -B]PYRR0L-3-ONES AS CATHEPSIN K INHIBITORS | Amura Therapeutics Limited (GB) | 2009-04-15 | — | — | EP | disclosed |
| EP-2046795-A1 | FURO[3,2-B]PYRROL-3-ONE DERIVATIVES AND THEIR USE AS CYSTEINYL PROTEINASE INHIBITORS | Amura Therapeutics Limited (GB) | 2009-04-15 | — | — | EP | disclosed |
| EP-2046798-A1 | FURO [3,2-B]PYRROL-3-ONE DERIVATIVES AND THEIR USE AS CYSTEINYL PROTEINASE INHIBITORS | Amura Therapeutics Limited (GB) | 2009-04-15 | — | — | EP | disclosed |
| EP-2044075-A1 | FURO [3, 2-B] PYRROL DERIVATIVES | Amura Therapeutics Limited (GB) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008007132-A1 | TETRAHYDROFURO [3, 2-B] PYRR0L-3-0NE INTERMEDIATES | AMURA THERAPEUTICS LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |
| WO-2008007114-A1 | TETRAHYDROFURO [3, 2 -B] PYRR0L-3-ONES AS CATHEPSIN K INHIBITORS | AMURA THERAPEUTICS LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |
| WO-2008007103-A1 | FURO [3, 2-B] PYRROL DERIVATIVES | AMURA THERAPEUTICS LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |
| WO-2008007109-A1 | FURO[3,2-B]PYRROL-3-ONE DERIVATIVES AND THEIR USE AS CYSTEINYL PROTEINASE INHIBITORS | AMURA THERAPEUTICS LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |
| WO-2008007130-A1 | FURO [3,2-B] PYRROL-3-ONE DERIVATIVES AND THEIR USE AS CYSTEINYL PROTEINASE INHIBITORS | AMURA THERAPEUTICS LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |
| WO-2008007112-A1 | TETRAHYDROFURO [3, 2-B] PYRR0L-3-ONES AS CATHEPSIN K INHIBITORS | AMURA THERAPEUTICS LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |