SCHEMBL13245641

SCHEMBL13245641

c1ccc2c(c1)c1ccccc1n2-c1ccc2oc3c(-n4c5ccccc5c5cc(-n6c7ccccc7c7ccccc76)ccc54)nccc3c2c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 3/20 0.35
▸ ATM Q13315 1/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ TSHR P16473 4/20 0.34
▸ LMNA P02545 4/20 0.34
▸ MAPT P10636 3/20 0.34
▸ NPC1 O15118 2/20 0.34
▸ ALDH1A1 P00352 4/20 0.33
▸ HTT P42858 3/20 0.33
▸ HPGD P15428 2/20 0.33
▸ HSD17B10 Q99714 2/20 0.33
▸ MEN1 O00255 2/20 0.33
▸ KMT2A Q03164 2/20 0.33
▸ SMN1; SMN2 Q16637 2/20 0.33
▸ HCRTR1 O43613 1/20 0.33
▸ TP53 P04637 1/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ PPARG P37231 2/20 0.32
▸ RXFP1 Q9HBX9 2/20 0.32
▸ NR2E3 Q9Y5X4 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13245640 1.00 KDM4E (0.35) KDM4EATML3MBTL1TSHRLMNA
SCHEMBL13245633 0.97 KDM4E (0.37) KDM4EATML3MBTL1TSHRLMNA
SCHEMBL10451079 0.95 KDM4E (0.35) KDM4EATML3MBTL1TSHRLMNA
SCHEMBL25752007 0.93 ALDH1A1 (0.35) KDM4EATML3MBTL1TSHRLMNA
SCHEMBL25752012 0.91 ALDH1A1 (0.34) KDM4ETSHRLMNAMAPTNPC1
SCHEMBL25752010 0.91 ALDH1A1 (0.34) KDM4ETSHRLMNAMAPTNPC1
SCHEMBL22036765 0.90 KDM4E (0.37) KDM4EATML3MBTL1TSHRMAPT
SCHEMBL22294725 0.89 MCL1 (0.38) L3MBTL1TSHRLMNAMAPTALDH1A1
SCHEMBL25752006 0.89 ALDH1A1 (0.35) KDM4EATML3MBTL1TSHRLMNA
SCHEMBL10449626 0.88 KDM4E (0.32) KDM4EATML3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3689882-A1 NEW MATERIALS WITH AZA-DIBENZOTHIOPHENE OR AZA-DIBENZOFURAN CORE FOR PHOLED Universal Display Corporation (US) 2020-08-05 — — EP disclosed
US-9831442-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2017-11-28 — — US disclosed
US-9831442-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2017-11-28 — — US disclosed
US-20170077417-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2017-03-16 — — US disclosed
US-20170077417-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2017-03-16 — — US disclosed
US-9518063-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2016-12-13 — — US disclosed
US-9518063-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2016-12-13 — — US disclosed
EP-2387576-B1 NEW MATERIALS WITH AZA-DIBENZOTHIOPHENE OR AZA-DIBENZOFURAN CORE FOR PHOLED UNIVERSAL DISPLAY CORP (US) 2016-01-13 — — EP disclosed
US-20150274749-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2015-10-01 — — US disclosed
US-20150274749-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2015-10-01 — — US disclosed
US-9067947-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2015-06-30 — — US disclosed
US-9067947-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2015-06-30 — — US disclosed
US-8952363-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2015-02-10 — — US disclosed
US-8952363-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2015-02-10 — — US disclosed
EP-2703405-A2 New materials with aza-dibenzothiophene or aza-dibenzofuran core for pholed Universal Display Corporation (US) 2014-03-05 — — EP disclosed
US-20130060037-A1 MATERIALS WITH AZA-DIBENZOTHIOPHENE OR AZA-DIBENZOFURAN CORE FOR PHOLED UNIVERSAL DISPLAY CORPORATION (US) 2013-03-07 — — US disclosed
US-20130060037-A1 MATERIALS WITH AZA-DIBENZOTHIOPHENE OR AZA-DIBENZOFURAN CORE FOR PHOLED UNIVERSAL DISPLAY CORPORATION (US) 2013-03-07 — — US disclosed
US-20100187984-A1 MATERIALS WITH AZA-DIBENZOTHIOPHENE OR AZA-DIBENZOFURAN CORE FOR PHOLED UNIVERSAL DISPLAY CORPORATION (US) 2010-07-29 — — US disclosed
US-20100187984-A1 MATERIALS WITH AZA-DIBENZOTHIOPHENE OR AZA-DIBENZOFURAN CORE FOR PHOLED UNIVERSAL DISPLAY CORPORATION (US) 2010-07-29 — — US disclosed
WO-2010083359-A2 NEW MATERIALS WITH AZA-DIBENZOTHIOPHENE OR AZA-DIBENZOFURAN CORE FOR PHOLED UNIVERSAL DISPLAY CORPORATION (US) 2010-07-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170077417-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES DDT, AZI2, EED KDM4E 306/4885ATM 4245/4885L3MBTL1 267/4885
US-20150274749-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES DDT, AZI2, EED KDM4E 306/4885ATM 4245/4885L3MBTL1 267/4885
US-20130060037-A1 MATERIALS WITH AZA-DIBENZOTHIOPHENE OR AZA-DIBENZOFURAN CORE FOR PHOLED DDT, FZD7, BRD7 KDM4E 832/4885ATM 4671/4885L3MBTL1 635/4885
US-20100187984-A1 MATERIALS WITH AZA-DIBENZOTHIOPHENE OR AZA-DIBENZOFURAN CORE FOR PHOLED DDT, FZD7, BRD7 KDM4E 832/4885ATM 4671/4885L3MBTL1 635/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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