FZD7 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL3253804	0.63	1/20
SCHEMBL14102516	0.61	1/20
SCHEMBL14102671	0.61	1/20
SCHEMBL16607179	0.59	1/20
SCHEMBL3344724	0.57	1/20
SCHEMBL11614641	0.55	1/20
SCHEMBL8452345	0.54	1/20
SCHEMBL24209795	0.54	1/20
Hydrochloric Acid (SCHEMBL6038120)	0.53	1/20
SCHEMBL16434543	0.52	1/20
Trifluoroacetic Acid (SCHEMBL3170055)	0.50	1/20
SCHEMBL14592021	0.50	1/20
SCHEMBL5698591	0.49	1/20
Trifluoroacetic Acid (SCHEMBL3173772)	0.49	1/20
SCHEMBL5717756	0.49	1/20
SCHEMBL21224471	0.48	1/20
SCHEMBL21224472	0.48	1/20
SCHEMBL21241835	0.48	1/20
SCHEMBL5717639	0.48	1/20
SCHEMBL22971735	0.47	1/20

Clinical trials — most relevant to FZD7 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Cornelia De Lange Syndrome: Assessing Positive Effects of Lithium Treatment	PHASE2/PHASE3	RECRUITING
Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy	PHASE2	RECRUITING
Mesalazine Effects in Sporadic Colorectal Adenoma Patients	PHASE2	COMPLETED
CAR-T Cell Therapy Targeting GPC3 in Patients with Advanced GPC3-Positive Hepatocellular Carcinoma	PHASE1/PHASE2	NOT_YET_RECRUITING
Comparing of Sesame Oil, Nitroglycerin Ointment, and Aloe Vera Gel	PHASE2	NOT_YET_RECRUITING
Gefitinib in Treating Patients With Progressive Metastatic Neuroendocrine Tumors	PHASE2	COMPLETED
Obeticholic Acid in Bile Acid Diarrhoea	PHASE2	COMPLETED
Phase 2 Study Evaluating the Efficacy of the Combination of DKN-01 (DKK1 Inhibitor, Leap Therapeutics) and Pembrolizumab in the Treatment of Advanced or Recurrent Endometrial Cancer	PHASE2	ACTIVE_NOT_RECRUITING
Dovitinib(TKI258) in Patients With Castration-resistant Prostate Cancer	PHASE2	COMPLETED
Study of Vismodegib in Advanced Gastric Adenocarcinoma Patients With SMO Overexpression	PHASE2	COMPLETED
Phase I Study to Evaluate Safety, Tolerability, Anti-Tumour Activity and PK Profiles of Foxy-5 in Metastatic Breast, Colon or Prostate Cancer	PHASE1	COMPLETED
Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetic Profile of XNW7201 in Subjects With Advanced Solid Tumors	PHASE1	COMPLETED
Safety and Efficacy Study of PRI-724 Plus Gemcitabine in Subjects With Advanced or Metastatic Pancreatic Adenocarcinoma	PHASE1	COMPLETED
Treatment Duration Increment and Pharmacodynamic Study of CX-4945 in Patients With Basal Cell Carcinoma (BCC)	PHASE1	COMPLETED
A Phase 1-2 of ST316 With Selected Advanced Unresectable and Metastatic Solid Tumors	PHASE1	RECRUITING
FOLFIRINOX Plus IPI-926 for Advanced Pancreatic Adenocarcinoma	PHASE1	COMPLETED
Klotho _ LRP-6 _ Gastric Adenocarcinoma	nan	UNKNOWN
Effect of Mechanical Ventilation on Plasma Concentration Level of R-spondin Proteins	nan	COMPLETED
Clinical Significance of DKK2 Protein in Cerebral Ischemia-reperfusion Injury	nan	UNKNOWN
Bone Markers and Bone Density Changes in Hyperperparathyroid Dialysis Patients Under Cinacalcet Treatment	nan	COMPLETED
Osteogenic Effects in Human Mesenchymal Stem Cells Enhanced by Wnt Signaling	nan	COMPLETED
Predictive Value of E-cadherin, β-catenin and SOX4 in Recurrence and/or Progression of Non-muscle Invasive Urinary Bladder Transitional Cell Carcinoma. A Retrospective Study	nan	COMPLETED
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact	nan	UNKNOWN
A Pilot Study of Berberine (Soloways ™) in Patients with Type 2 Diabetes Mellitus Carrying TCF7L2 Polymorphisms	nan	COMPLETED
Exploratory Study of Rectal Mucus for Diagnosing Disease	nan	COMPLETED
Focal Radiotherapy Plus Low Dose Craniospinal Irradiation Followed by Adjuvant Chemotherapy in WNT Medulloblastoma.	nan	RECRUITING
A Case Control Study of Resveratrol Effects in Coronary Artery Disease Patients With Metabolic Syndrome	nan	COMPLETED
Unusual Infiltrative Patterns of Malignant Cells in Endometrial Carcinoma and Immunohistochemical Expression of P53	nan	UNKNOWN
Emerging Role of NOTCH-related Long Non-coding RNA(s) as Biomarkers in Liquid Biopsy From Colorectal Cancer Patients	nan	COMPLETED
Eosinophil Induced Remodelling in Asthma	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a FZD7 binder may also engage these)

Protein	Name	Similarity
O57329	—	1.000	O57329 →
Q61090	—	1.000	Q61090 →
O57328	—	1.000	O57328 →
Q08464	—	1.000	Q08464 →
Q8AVJ9	—	1.000	Q8AVJ9 →
O70421	—	0.999	O70421 →
Q08463	—	0.997	Q08463 →
Q9R216	—	0.997	Q9R216 →
Q5BL72	—	0.996	Q5BL72 →
Q9PUK8	—	0.996	Q9PUK8 →
Q8K4C8	—	0.995	Q8K4C8 →
Q14332	—	0.995	Q14332 →
Q8CHL0	—	0.994	Q8CHL0 →
O00144	—	0.994	O00144 →
Q9JIP6	—	0.993	Q9JIP6 →
B3DIG4	—	0.992	B3DIG4 →
Q24760	—	0.992	Q24760 →
P18537	—	0.991	P18537 →
Q9EQD0	—	0.991	Q9EQD0 →
Q9H461	—	0.991	Q9H461 →
Q13467	—	0.990	Q13467 →
Q9IA06	—	0.990	Q9IA06 →
Q8BKG4	—	0.990	Q8BKG4 →
Q498S8	—	0.989	Q498S8 →
Q9I9M5	—	0.988	Q9I9M5 →
Q9UP38	—	0.987	Q9UP38 →
Q9ULW2	—	0.986	Q9ULW2 →
O93274	—	0.982	O93274 →
Q9PUU6	—	0.979	Q9PUU6 →
Q61091	—	0.976	Q61091 →