Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | PLA2G4B | P0C869 | 6/20 | 0.67 |
| ▸ | RARB | P10826 | 3/20 | 0.63 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.60 |
| ▸ | THRA | P10827 | 2/20 | 0.57 |
| ▸ | THRB | P10828 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15503238 | 1.00 | TP53 (0.69) | TP53TSHRPLA2G4BRARBPLA2G4A | |
| SCHEMBL13246799 | 1.00 | TP53 (0.69) | TP53TSHRPLA2G4BRARBPLA2G4A | |
| SCHEMBL13246802 | 1.00 | TP53 (0.69) | TP53TSHRPLA2G4BRARBPLA2G4A | |
| SCHEMBL13246800 | 1.00 | TP53 (0.69) | TP53TSHRPLA2G4BRARBPLA2G4A | |
| SCHEMBL13246801 | 1.00 | TP53 (0.69) | TP53TSHRPLA2G4BRARBPLA2G4A | |
| SCHEMBL13246836 | 0.95 | RARB (0.71) | TP53TSHRPLA2G4BRARBPLA2G4A | |
| SCHEMBL13246833 | 0.95 | RARB (0.71) | TP53TSHRPLA2G4BRARBPLA2G4A | |
| SCHEMBL13246840 | 0.95 | RARB (0.71) | TP53TSHRPLA2G4BRARBPLA2G4A | |
| SCHEMBL11892064 | 0.94 | RARB (0.68) | TP53TSHRPLA2G4BRARBPLA2G4A | |
| SCHEMBL13246825 | 0.94 | RARB (0.68) | TP53TSHRPLA2G4BRARBPLA2G4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150337013-A1 | NOVEL ANTIBACTERIAL AGENTS FOR THE TREATMENT OF GRAM POSITIVE INFECTIONS | MERCK SHARP & DOHME CORP. (US) | 2015-11-26 | — | — | US | disclosed |
| US-20140073558-A1 | NOVEL ANTIBACTERIAL AGENTS FOR THE TREATMENT OF GRAM POSITIVE INFECTIONS | CUBIST PHARMACEUTICALS, INC. (US) | 2014-03-13 | — | — | US | disclosed |
| US-8507647-B2 | Antibacterial agents for the treatment of gram positive infections | CUBIST PHARMACEUTICALS, INC. (US) | 2013-08-13 | — | — | US | disclosed |
| US-20100184649-A1 | NOVEL ANTIBACTERIAL AGENTS FOR THE TREATMENT OF GRAM POSITIVE INFECTIONS | CUBIST PHARMACEUTICALS, INC. | 2010-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150337013-A1 | NOVEL ANTIBACTERIAL AGENTS FOR THE TREATMENT OF GRAM POSITIVE INFECTIONS | CLPP, CLPTM1, RPN1 | TP53 4408/4885TSHR 4677/4885PLA2G4B 1406/4885 |
| US-20100184649-A1 | NOVEL ANTIBACTERIAL AGENTS FOR THE TREATMENT OF GRAM POSITIVE INFECTIONS | CLPP, CLPTM1, RPN1 | TP53 4408/4885TSHR 4677/4885PLA2G4B 1406/4885 |
| US-20140073558-A1 | NOVEL ANTIBACTERIAL AGENTS FOR THE TREATMENT OF GRAM POSITIVE INFECTIONS | CLPP, CLPTM1, RPN1 | TP53 4408/4885TSHR 4677/4885PLA2G4B 1406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.