Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.32 |
| ▸ | SHBG | P04278 | 3/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | FABP4 | P15090 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.31 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.31 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.31 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31058464 | 0.84 | ATM (0.51) | ATMCYP19A1SHBGRECQLCYP3A4 | |
| SCHEMBL1231104 | 0.81 | KMT2A (0.39) | ATMKMT2AMEN1 | |
| SCHEMBL13251204 | 0.78 | CYP19A1 (0.41) | STAT3CYP19A1RECQLARESR2 | |
| SCHEMBL19222394 | 0.76 | ICAM1 (0.38) | ATMSTAT3CYP19A1SHBGRECQL | |
| Reynosin SCHEMBL1683362 | 0.73 | PKM (0.51) | STAT3CYP19A1CYP3A4TP53KMT2A | |
| Reynosin SCHEMBL1683363 | 0.73 | PKM (0.51) | STAT3CYP19A1CYP3A4TP53KMT2A | |
| Reynosin SCHEMBL28633984 | 0.73 | PKM (0.51) | STAT3CYP19A1CYP3A4TP53KMT2A | |
| SCHEMBL19222395 | 0.68 | CYP19A1 (0.34) | ATMSTAT3CYP19A1RECQL | |
| SCHEMBL18923697 | 0.65 | — | — | |
| SCHEMBL17086994 | 0.63 | TAS2R46 (0.39) | STAT3CYP3A4TP53KMT2ANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150099731-A1 | USE OF PARTHENOLIDE DERIVATIVES AS ANTILEUKEMIC AND CYTOTOXIC AGENTS | UNIVERSITY OF KENTUCKY (US) | 2015-04-09 | — | — | US | disclosed |
| US-20130288371-A1 | USE OF PARTHENOLIDE DERIVATIVES AS ANTILEUKEMIC AND CYTOTOXIC AGENTS | UNIV KENTUCKY (US) | 2013-10-31 | — | — | US | disclosed |
| US-8470875-B2 | Use of parthenolide derivatives as antileukemic and cytotoxic agents | UNIVERSITY OF KENTUCKY (US) | 2013-06-25 | — | — | US | disclosed |
| US-20100184745-A1 | USE OF PARTHENOLIDE DERIVATIVES AS ANTILEUKEMIC AND CYTOTOXIC AGENTS | UNIVERSITY OF KENTUCKY (US) | 2010-07-22 | — | — | US | disclosed |
| US-7678904-B2 | or to treat autoimmune and inflammatory disorders; improved water solubility characteristics | UNIVERSITY OF KENTUCKY (US) | 2010-03-16 | — | — | US | disclosed |
| US-7312242-B2 | Use of parthenolide derivatives as antileukemic and cytotoxic agents | UNIVERSITY OF KENTUCKY (US) | 2007-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184745-A1 | USE OF PARTHENOLIDE DERIVATIVES AS ANTILEUKEMIC AND CYTOTOXIC AGENTS | NR1H2, NR1H3, NCOR2 | ATM 2768/4885STAT3 237/4885CYP19A1 664/4885 |
| US-20130288371-A1 | USE OF PARTHENOLIDE DERIVATIVES AS ANTILEUKEMIC AND CYTOTOXIC AGENTS | NR1H2, NR1H3, NCOR2 | ATM 2934/4885STAT3 243/4885CYP19A1 673/4885 |
| US-20150099731-A1 | USE OF PARTHENOLIDE DERIVATIVES AS ANTILEUKEMIC AND CYTOTOXIC AGENTS | NR1H2, NR1H3, NCOR2 | ATM 2934/4885STAT3 243/4885CYP19A1 673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.