Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.72 |
| ▸ | CDK2 | P24941 | 1/20 | 0.72 |
| ▸ | CDK8 | P49336 | 1/20 | 0.72 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 5/20 | 0.52 |
| ▸ | KIT | P10721 | 4/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 5/20 | 0.50 |
| ▸ | ABL1 | P00519 | 4/20 | 0.50 |
| ▸ | HCK | P08631 | 1/20 | 0.49 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29678277 | 0.84 | CDK2 (1.00) | CDK1CDK2CDK8KDRSRC | |
| SCHEMBL3676641 | 0.84 | CDK2 (1.00) | CDK1CDK2CDK8KDRSRC | |
| SCHEMBL1325391 | 0.84 | KDR (0.65) | CDK1CDK2CDK8KDRKIT | |
| SCHEMBL2437488 | 0.83 | KDR (0.78) | CDK1CDK2CDK8KDRSRC | |
| SCHEMBL1325406 | 0.83 | KDR (0.66) | CDK1CDK2CDK8KDRSRC | |
| SCHEMBL1324760 | 0.82 | CDK1 (0.72) | CDK1CDK2CDK8KDRSRC | |
| SCHEMBL1324080 | 0.82 | CDK1 (0.72) | CDK1CDK2CDK8KDRSRC | |
| SCHEMBL1324041 | 0.80 | CDK1 (0.72) | CDK1CDK2CDK8KDRSRC | |
| SCHEMBL1324365 | 0.79 | KDR (0.67) | KDRKITBRAFRET | |
| SCHEMBL3681671 | 0.78 | CDK2 (0.88) | CDK1CDK2CDK8KDRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058276-B2 | Heterobicyclic carboxamides as inhibitors for kinases | NOVARTIS AG (CH) | 2011-11-15 | — | — | US | disclosed |