Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.72 |
| ▸ | CDK2 | P24941 | 1/20 | 0.72 |
| ▸ | CDK8 | P49336 | 1/20 | 0.72 |
| ▸ | KDR | P35968 | 3/20 | 0.60 |
| ▸ | SRC | P12931 | 5/20 | 0.53 |
| ▸ | FLT1 | P17948 | 2/20 | 0.52 |
| ▸ | FLT4 | P35916 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 4/20 | 0.52 |
| ▸ | KIT | P10721 | 6/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 3/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1325318 | 0.91 | CDK1 (0.59) | CDK1CDK2CDK8KDRSRC | |
| SCHEMBL2437488 | 0.88 | KDR (0.78) | CDK1CDK2CDK8KDRSRC | |
| SCHEMBL1324080 | 0.86 | CDK1 (0.72) | CDK1CDK2CDK8KDRSRC | |
| SCHEMBL29678277 | 0.84 | CDK2 (1.00) | CDK1CDK2CDK8KDRSRC | |
| SCHEMBL3676641 | 0.84 | CDK2 (1.00) | CDK1CDK2CDK8KDRSRC | |
| SCHEMBL1325272 | 0.84 | KDR (0.61) | CDK1CDK2CDK8KDRFLT1 | |
| SCHEMBL1324041 | 0.84 | CDK1 (0.72) | CDK1CDK2CDK8KDRSRC | |
| SCHEMBL1324954 | 0.83 | KDR (0.73) | CDK1CDK2CDK8KDRFLT1 | |
| SCHEMBL1325191 | 0.82 | CDK1 (0.72) | CDK1CDK2CDK8KDRSRC | |
| SCHEMBL2436659 | 0.80 | CDK2 (0.72) | CDK1CDK2CDK8KDRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058276-B2 | Heterobicyclic carboxamides as inhibitors for kinases | NOVARTIS AG (CH) | 2011-11-15 | — | — | US | disclosed |
| WO-2008009487-A1 | HETEROBICYCLIC CARBOXAMIDES AS INHIBITORS FOR KINASES | NOVARTIS AG (CH) | 2008-01-24 | — | — | WO | disclosed |