Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | PGK1 | P00558 | 2/20 | 0.43 |
| ▸ | PGK2 | P07205 | 2/20 | 0.43 |
| ▸ | GBA1 | P04062 | 4/20 | 0.42 |
| ▸ | PDE5A | O76074 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CCNK | O75909 | 8/20 | 0.40 |
| ▸ | CDK12 | Q9NYV4 | 8/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2317411 | 1.00 | PIK3CA (0.44) | PIK3CAMTORPIK3CGPGK1PGK2 | |
| SCHEMBL13253978 | 1.00 | PIK3CA (0.44) | PIK3CAMTORPIK3CGPGK1PGK2 | |
| SCHEMBL2315257 | 0.93 | PGK1 (0.45) | PIK3CAMTORPIK3CGPGK1PGK2 | |
| SCHEMBL2313935 | 0.91 | GBA1 (0.46) | PIK3CAMTORPIK3CGPGK1PGK2 | |
| SCHEMBL2314682 | 0.87 | PIK3CA (0.44) | PIK3CAMTORPIK3CGPGK1PGK2 | |
| SCHEMBL2314694 | 0.87 | PIK3CA (0.44) | PIK3CAMTORPIK3CGPGK1PGK2 | |
| SCHEMBL2313576 | 0.87 | PIK3CA (0.44) | PIK3CAMTORPIK3CGPGK1PGK2 | |
| SCHEMBL2313861 | 0.86 | PIK3CA (0.45) | PIK3CAMTORPIK3CGPGK1PGK2 | |
| SCHEMBL2318500 | 0.82 | CYP2D6 (0.47) | PGK1PGK2ADORA3 | |
| SCHEMBL2318493 | 0.82 | CYP2D6 (0.47) | PGK1PGK2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210187033-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | NOVARTIS AG (CH) | 2021-06-24 | — | — | US | disclosed |
| US-20180142212-A1 | COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS | FRED HUTCHINSON CANCER RESEARCH CENTER | 2018-05-24 | — | — | US | disclosed |
| US-9834755-B2 | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2017-12-05 | — | — | US | disclosed |
| US-20170239296-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | NOVARTIS AG (CH) | 2017-08-24 | — | — | US | disclosed |
| US-9580426-B2 | Compounds that expand hematopoietic stem cells | NOVARTIS AG (CH) | 2017-02-28 | — | — | US | disclosed |
| US-8927281-B2 | Method for expanding hematopoietic stem cells | IRM LLC (BM) | 2015-01-06 | — | — | US | disclosed |
| US-8927281-B2 | Method for expanding hematopoietic stem cells | IRM LLC (BM) | 2015-01-06 | — | — | US | disclosed |
| US-20140369973-A1 | COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2014-12-18 | — | — | US | disclosed |
| US-20140114070-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-04-24 | — | — | US | disclosed |
| US-20100183564-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | IRM LLC (BM) | 2010-07-22 | — | — | US | disclosed |
| US-20100183564-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | IRM LLC (BM) | 2010-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140369973-A1 | COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS | AHR, NOTCH1, ARNT | PIK3CA 2527/4885MTOR 4383/4885PIK3CG 2849/4885 |
| US-20170239296-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | CD47, HCLS1, CD74 | PIK3CA 1299/4885MTOR 1140/4885PIK3CG 1258/4885 |
| US-20210187033-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | CD47, HCLS1, CD74 | PIK3CA 1299/4885MTOR 1140/4885PIK3CG 1258/4885 |
| US-20140114070-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | CD47, HCLS1, CD74 | PIK3CA 1299/4885MTOR 1140/4885PIK3CG 1258/4885 |
| US-20100183564-A1 | COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS | CD47, HCLS1, CD74 | PIK3CA 1299/4885MTOR 1140/4885PIK3CG 1258/4885 |
| US-20180142212-A1 | COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS | AHR, NOTCH1, ARNT | PIK3CA 2527/4885MTOR 4383/4885PIK3CG 2849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.