Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | MPI | P34949 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13255442 | 0.84 | MAPK14 (0.38) | MAPK14POLBPARP1L3MBTL1RAB9A | |
| SCHEMBL13255450 | 0.78 | RAB9A (0.48) | MAPK14POLBPARP1KDM4EL3MBTL1 | |
| SCHEMBL12020169 | 0.76 | MEN1 (0.41) | POLBPARP1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL13255593 | 0.70 | PARP1 (0.40) | MAPK14POLBPARP1KDM4EL3MBTL1 | |
| SCHEMBL13255451 | 0.64 | HPGD (0.47) | MAPK14POLBKDM4EL3MBTL1RAB9A | |
| SCHEMBL13255381 | 0.64 | MEN1 (0.36) | POLBHPGDSMN1; SMN2HDAC6KMT2A | |
| SCHEMBL14046419 | 0.63 | HDAC6 (0.35) | POLBRAB9AHPGDHDAC6KMT2A | |
| SCHEMBL13851051 | 0.62 | KMT2A (0.49) | L3MBTL1KMT2AMEN1ALDH1A1 | |
| SCHEMBL13255478 | 0.61 | HPGD (0.47) | POLBKDM4EL3MBTL1RAB9AHPGD | |
| SCHEMBL967039 | 0.61 | RAB9A (0.46) | POLBKDM4EL3MBTL1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7759372-B2 | Nitrogen-containing heteroaryl compounds having inhibitory activity against HIV integrase | SHIONOGI & CO., LTD. (JP) | 2010-07-20 | — | — | US | disclosed |
| US-7759372-B2 | Nitrogen-containing heteroaryl compounds having inhibitory activity against HIV integrase | SHIONOGI & CO., LTD. (JP) | 2010-07-20 | — | — | US | disclosed |
| EP-2033952-A1 | Nitrogen-containing Heteroaryl compounds having HIV Integrase Inhibitory Activity | Shionogi&Co., Ltd. (JP) | 2009-03-11 | — | — | EP | disclosed |