Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 9/20 | 0.51 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14355146 | 0.83 | IDO1 (0.73) | IDO1NOS1BACE1SLC11A2 | |
| SCHEMBL15457415 | 0.77 | IDO1 (0.50) | IDO1NOS1MAPTMAPK1BACE1 | |
| Hydrochloric Acid SCHEMBL3395144 | 0.76 | IDO1 (0.52) | IDO1NOS1BACE1SLC11A2 | |
| SCHEMBL17198979 | 0.74 | SIGMAR1 (0.41) | IDO1MAPTMAPK1 | |
| SCHEMBL13256337 | 0.74 | IDO1 (0.50) | IDO1MAPTBACE1 | |
| SCHEMBL13256348 | 0.74 | BACE1 (0.71) | IDO1MAPK1BACE1ALDH1A1 | |
| SCHEMBL13256318 | 0.74 | SLC11A2 (0.44) | IDO1NOS1SLC11A2 | |
| SCHEMBL13256346 | 0.74 | IDO1 (0.53) | IDO1MAPK1 | |
| Benzylamidinoisothiourea SCHEMBL13460125 | 0.73 | IDO1 (0.62) | IDO1NOS1SLC11A2ALDH1A1 | |
| Benzylamidinoisothiourea SCHEMBL10658003 | 0.72 | IDO1 (0.63) | IDO1NOS1SLC11A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100184851-A1 | INHIBITION OF CELL PROLIFERATION | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-07-22 | — | — | US | disclosed |
| US-20100184851-A1 | INHIBITION OF CELL PROLIFERATION | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-07-22 | — | — | US | disclosed |
| WO-2010025448-A2 | INHIBITION OF CELL PROLIFERATION | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184851-A1 | INHIBITION OF CELL PROLIFERATION | MKI67, RB1, RAF1 | IDO1 4276/4885NOS1 4083/4885MAPT 3965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.