Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 8/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13256339 | 0.85 | IDO1 (0.40) | IDO1HTTSMN1; SMN2MAPTKDM4E | |
| SCHEMBL13256341 | 0.85 | IDO1 (0.69) | IDO1HTTALOX15SMN1; SMN2LMNA | |
| SCHEMBL13256328 | 0.83 | IDO1 (0.71) | IDO1HTTALOX15CRHBPCRHR2 | |
| SCHEMBL13256346 | 0.77 | IDO1 (0.53) | IDO1HTTALOX15SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL3393753 | 0.76 | IDO1 (0.49) | IDO1HTTALOX15CRHBPCRHR2 | |
| SCHEMBL13256352 | 0.74 | IDO1 (0.51) | IDO1MAPTBACE1 | |
| SCHEMBL13256320 | 0.73 | CRHBP (0.43) | IDO1HTTCRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL13256348 | 0.71 | BACE1 (0.71) | IDO1HTTHSD17B10SMN1; SMN2LMNA | |
| SCHEMBL13283510 | 0.71 | IDO1 (0.47) | IDO1HTTALOX15SMN1; SMN2LMNA | |
| SCHEMBL21142097 | 0.71 | SMN1; SMN2 (0.47) | IDO1HTTALOX15CRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100184851-A1 | INHIBITION OF CELL PROLIFERATION | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-07-22 | — | — | US | disclosed |
| US-20100184851-A1 | INHIBITION OF CELL PROLIFERATION | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-07-22 | — | — | US | disclosed |
| WO-2010025448-A2 | INHIBITION OF CELL PROLIFERATION | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184851-A1 | INHIBITION OF CELL PROLIFERATION | MKI67, RB1, RAF1 | IDO1 4276/4885HTT 3856/4885ALOX15 3512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.