Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28848468 | 0.73 | SRD5A2 (0.30) | — | |
| SCHEMBL11370893 | 0.71 | ALDH1A1 (0.32) | MGAMGAASIMGAM2KMT2A | |
| SCHEMBL28396190 | 0.67 | MEN1 (0.33) | MGAMGAASIMGAM2KMT2A | |
| SCHEMBL11543791 | 0.67 | KDM4E (0.37) | GAAKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL28802419 | 0.63 | KDM4E (0.39) | GAAKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL3405646 | 0.63 | POLB (0.50) | MGAMGAASIMGAM2KMT2A | |
| SCHEMBL29066545 | 0.63 | KDM4E (0.36) | KMT2AKDM4EMEN1ALDH1A1ALOX15 | |
| Malonic Acid Diethyl Ester SCHEMBL27672071 | 0.62 | GAA (0.94) | MGAMGAASIMGAM2KMT2A | |
| Malonic Acid Diethyl Ester SCHEMBL4334303 | 0.62 | GAA (0.94) | MGAMGAASIMGAM2KMT2A | |
| SCHEMBL31281314 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010091009-A1 | ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2010-08-12 | — | — | WO | disclosed |