Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL953679 | 0.92 | TGFBR1 (0.40) | PIK3CAMTORALPLGSK3BGSK3A | |
| SCHEMBL957235 | 0.82 | ALPL (0.43) | PIK3CAMTORALPLGSK3BGSK3A | |
| SCHEMBL13257597 | 0.82 | PIK3C3 (0.41) | ALPLCYP3A4SCN9APIK3C3TGFBR1 | |
| SCHEMBL12918242 | 0.79 | PIK3C3 (0.39) | ALPLCYP3A4PIK3C3TGFBR1TGFBR2 | |
| SCHEMBL12918108 | 0.77 | PIK3CA (0.39) | PIK3CAMTORGSK3BGSK3ADYRK1A | |
| SCHEMBL12918088 | 0.77 | PIK3CA (0.39) | PIK3CAMTORGSK3BGSK3ADYRK1A | |
| SCHEMBL12947729 | 0.76 | PIK3C3 (0.40) | PIK3CAMTORCYP3A4PIK3C3TGFBR1 | |
| SCHEMBL955529 | 0.75 | TGFBR1 (0.40) | PIK3CAMTORGSK3BGSK3AKMT2A | |
| SCHEMBL952919 | 0.75 | PIK3C3 (0.40) | PIK3CAMTORGSK3BGSK3ACYP3A4 | |
| SCHEMBL13105669 | 0.75 | PIK3CA (0.36) | PIK3CAMTORGSK3BGSK3ADYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010090716-A1 | HETEROARYLS AND THEIR USE AS PI3K INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-08-12 | — | — | WO | disclosed |