Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 7/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13258579 | 0.89 | ROCK2 (0.40) | ROCK2NAMPTROCK1RXFP1KMT2A | |
| SCHEMBL3786977 | 0.77 | EPHX2 (0.47) | ROCK2ROCK1 | |
| SCHEMBL3795177 | 0.75 | DDR1 (0.43) | ROCK2NAMPTROCK1 | |
| SCHEMBL3785014 | 0.74 | DDR1 (0.46) | NAMPT | |
| SCHEMBL3794531 | 0.74 | ROCK2 (0.47) | ROCK2ROCK1BRD4 | |
| SCHEMBL13258576 | 0.72 | DDR1 (0.41) | ROCK2ROCK1 | |
| SCHEMBL13258575 | 0.72 | DDR1 (0.41) | ROCK2ROCK1 | |
| SCHEMBL3792501 | 0.66 | CNR2 (0.48) | ROCK2ROCK1 | |
| SCHEMBL5723909 | 0.64 | HPGD (0.67) | KMT2AMEN1TSHR | |
| SCHEMBL30646449 | 0.64 | HPGD (0.67) | KMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | disclosed |