Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.58 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | TTR | P02766 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30646449 | 1.00 | HPGD (0.67) | HPGDALDH1A1ERCC1ERCC4GAA | |
| SCHEMBL8339658 | 0.90 | SMN1; SMN2 (0.70) | HPGDALDH1A1SMN1; SMN2HIF1AHDAC1 | |
| SCHEMBL12459658 | 0.86 | CA2 (0.52) | HPGDALDH1A1ERCC1ERCC4SMN1; SMN2 | |
| SCHEMBL14817912 | 0.86 | ALDH1A1 (0.51) | HPGDALDH1A1ERCC1ERCC4SMN1; SMN2 | |
| SCHEMBL14817978 | 0.86 | ALDH1A1 (0.59) | HPGDALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL15911107 | 0.83 | SYK (0.69) | HPGDALDH1A1ERCC1ERCC4GAA | |
| SCHEMBL4839587 | 0.82 | TSHR (0.59) | HPGDALDH1A1KMT2AMEN1CYP2D6 | |
| SCHEMBL1813320 | 0.82 | RAB9A (0.60) | GAASMN1; SMN2KMT2AMEN1HIF1A | |
| SCHEMBL3389986 | 0.81 | HPGD (0.57) | HPGDALDH1A1GAASMN1; SMN2KMT2A | |
| SCHEMBL10604929 | 0.81 | HPGD (0.67) | HPGDALDH1A1ERCC1ERCC4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633715-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | Pfizer Limited (GB) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004108676-A1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | PFIZER LIMITED (GB) | 2004-12-16 | — | — | WO | disclosed |