SCHEMBL1325844

SCHEMBL1325844

CC[SiH](CC)C(C)(C)CC

nearest known ligand 0.38

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.38
TDP1 Q9NUW8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27850598 0.73 TSHR (0.33) TSHRTDP1
SCHEMBL1325981 0.73
SCHEMBL1326087 0.71 TSHR (0.38) TSHRTDP1
SCHEMBL42436 0.69
SCHEMBL3217073 0.69 TSHR (0.43) TSHRTDP1
SCHEMBL9433116 0.67
SCHEMBL5833314 0.65 TSHR (0.32) TSHRTDP1
SCHEMBL25280700 0.64
SCHEMBL17024486 0.64 TSHR (0.38) TSHRTDP1
SCHEMBL25236500 0.64

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113906036-B Polycyclic aromatic compound, material for organic device, organic electroluminescent element, display device, and lighting device 学校法人关西学院 2024-10-25 CN disclosed
US-8058261-B2 3′-ethynylcytidine derivative TAIHO PHARMACEUTICAL CO., LTD. (JP) 2011-11-15 US disclosed
EP-2045258-B1 3'-ETHYNYLCYTIDINE DERIVATIVE TAIHO PHARMACEUTICAL CO LTD (JP) 2011-09-21 EP disclosed
US-7825103-B2 5'-O-triisopropylsilyl-2'-cyano-2'-deoxy-1- beta -D-arabinofuranosylcytosine; antitumor agents TAIHO PHARMACEUTICAL CO., LTD. (JP) 2010-11-02 US disclosed
US-20090306008-A1 3'-ETHYNYLCYTIDINE DERIVATIVE Sasaki, Takuma (JP) 2009-12-10 US disclosed
US-20090118222-A1 NOVEL PYRIMIDINE NUCLEOSIDE COMPOUND OR ITS SALT TAIHO PHARMACEUTICAL CO., LTD. (JP) 2009-05-07 US disclosed
EP-2045258-A1 3'-ETHYNYLCYTIDINE DERIVATIVE Taiho Pharmaceutical Co., Ltd. (JP) 2009-04-08 EP disclosed
EP-1845102-A1 NOVEL PYRIMIDINE NUCLEOSIDE COMPOUND OR ITS SALT TAIHO PHARMACEUTICAL COMPANY LIMITED (JP) 2007-10-17 EP disclosed
US-5317100-A Process for the preparation of optically active acyloxyazetidinones CIBA-GEIGY CORP. (US) 1994-05-31 US disclosed
EP-0181831-B1 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE ACYLOXYAZETIDINONES CIBA-GEIGY AG (CH) 1993-08-25 EP disclosed
EP-0367722-B1 PROCESS FOR PREPARING OPTICALLY ACTIVE ACYLOXYAZETIDINONES CIBA-GEIGY AG (CH) 1993-05-19 EP disclosed
EP-0126709-B1 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE AZETIDINONES CIBA-GEIGY AG (CH) 1991-04-03 EP disclosed
EP-0367722-A1 Process for preparing optically active acyloxyazetidinones CIBA-GEIGY AG (CH) 1990-05-09 EP disclosed
US-4614614-A Process for the manufacture of optically active azetidinones CIBA-GEIGY CORPORATION (US) 1986-09-30 US disclosed
EP-0181831-A2 Process for the preparation of optically active acyloxyazetidinones CIBA-GEIGY AG (CH) 1986-05-21 EP disclosed
EP-0126709-A1 Process for the preparation of optically active azetidinones CIBA-GEIGY AG (CH) 1984-11-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090118222-A1 NOVEL PYRIMIDINE NUCLEOSIDE COMPOUND OR ITS SALT CDK10, SRSF9, SNRPD1 TSHR 2261/4885TDP1 1736/4885
US-20090306008-A1 3'-ETHYNYLCYTIDINE DERIVATIVE SLC7A1, SLC29A1, SLC26A3 TSHR 719/4885TDP1 1360/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.