Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 9/20 | 0.56 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.56 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | CCNK | O75909 | 2/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13259773 | 0.86 | CHEK1 (0.69) | CHEK1MAPKAPK2IRAK4PDPK1RPS6KB1 | |
| SCHEMBL13258891 | 0.76 | CHEK1 (0.80) | CHEK1MAPKAPK2IRAK4PDPK1RPS6KB1 | |
| SCHEMBL13258882 | 0.76 | CHEK1 (0.81) | CHEK1MAPKAPK2IRAK4PDPK1RPS6KB1 | |
| SCHEMBL13258967 | 0.75 | CHEK1 (0.78) | CHEK1MAPKAPK2IRAK4PDPK1RPS6KB1 | |
| SCHEMBL13259792 | 0.74 | CHEK1 (0.67) | CHEK1MAPKAPK2IRAK4CYP1A2CYP2C19 | |
| SCHEMBL13258798 | 0.74 | CHEK1 (0.55) | CHEK1MAPKAPK2IRAK4LCK | |
| SCHEMBL13776792 | 0.74 | CHEK1 (0.75) | CHEK1MAPKAPK2IRAK4PDPK1RPS6KB1 | |
| SCHEMBL13258969 | 0.72 | CHEK1 (1.00) | CHEK1MAPKAPK2IRAK4KCNH2LCK | |
| SCHEMBL13258887 | 0.71 | CHEK1 (0.79) | CHEK1MAPKAPK2IRAK4PDPK1RPS6KB1 | |
| SCHEMBL5543550 | 0.71 | LRRK2 (0.40) | CHEK1MAPKAPK2IRAK4CDK2LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010088368-A2 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2010-08-05 | — | — | WO | disclosed |
| US-20090175852-A1 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION | 2009-07-09 | — | — | US | disclosed |
| US-20090175852-A1 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090175852-A1 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | CHEK1, CHEK2, CDKN1A | CHEK1 1/4885MAPKAPK2 43/4885IRAK4 275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.