Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.36 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5548905 | 0.79 | ADORA2A (0.39) | CYP1A2HSD17B10USP30PSDXDH | |
| SCHEMBL5550091 | 0.79 | GRM2 (0.43) | CYP1A2CYP2C19HSD17B10CLK4PSD | |
| SCHEMBL5548526 | 0.76 | EPHB4 (0.39) | CSNK2BCYP1A2HSD17B10PSDXDH | |
| SCHEMBL13258778 | 0.71 | CHEK1 (0.56) | LRRK2CYP1A2CYP2C19HSD17B10CLK4 | |
| SCHEMBL5545495 | 0.68 | TP53 (0.41) | LRRK2CLK4PIM1SRCGSK3B | |
| SCHEMBL1032832 | 0.66 | CTSK (0.57) | PIM1CCNA2CDK2GSK3BPRKD1 | |
| SCHEMBL3775368 | 0.65 | LRRK2 (0.58) | LRRK2CYP1A2CYP2C19HSD17B10CLK4 | |
| SCHEMBL5543611 | 0.65 | KDM5B (0.41) | HSD17B10MAPT | |
| SCHEMBL481517 | 0.63 | MTOR (0.66) | — | |
| SCHEMBL2032314 | 0.63 | CSNK2B (0.53) | CSNK2BPSDPIM1CDK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |