Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 18/20 | 0.75 |
| ▸ | MAPKAPK2 | P49137 | 8/20 | 0.75 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.51 |
| ▸ | TSSK2 | Q96PF2 | 1/20 | 0.51 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13258882 | 0.94 | CHEK1 (0.81) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13258891 | 0.90 | CHEK1 (0.80) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13258967 | 0.89 | CHEK1 (0.78) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13258887 | 0.88 | CHEK1 (0.79) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13258969 | 0.86 | CHEK1 (1.00) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13259783 | 0.83 | CHEK1 (1.00) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13764316 | 0.83 | CHEK1 (1.00) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13258870 | 0.83 | CHEK1 (1.00) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13776791 | 0.80 | CHEK1 (0.49) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13258778 | 0.74 | CHEK1 (0.56) | CHEK1MAPKAPK2LCKIRAK4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090175852-A1 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION | 2009-07-09 | — | — | US | disclosed |
| US-20090175852-A1 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090175852-A1 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | CHEK1, CHEK2, CDKN1A | CHEK1 1/4885MAPKAPK2 43/4885JAK2 71/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.