Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | OXTR | P30559 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.34 |
| ▸ | CLPP | Q16740 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13259017 | 0.85 | GPBAR1 (0.43) | GPBAR1KMT2A | |
| SCHEMBL13259977 | 0.83 | GPBAR1 (0.47) | RAB9AL3MBTL1GPBAR1GAAKMT2A | |
| SCHEMBL13259037 | 0.81 | ATM (0.32) | GPBAR1CLPPATM | |
| SCHEMBL10229677 | 0.81 | GPBAR1 (0.52) | OXTRLMNAL3MBTL1GPBAR1GAA | |
| SCHEMBL13259978 | 0.77 | GPBAR1 (0.41) | RAB9ALMNAGPBAR1GAAKMT2A | |
| SCHEMBL13259016 | 0.76 | SMN1; SMN2 (0.42) | RAB9ALMNAL3MBTL1GPBAR1 | |
| SCHEMBL13259018 | 0.70 | GPBAR1 (0.67) | LMNAGPBAR1KMT2A | |
| SCHEMBL13259019 | 0.67 | GPBAR1 (0.47) | LMNAL3MBTL1GPBAR1KMT2A | |
| SCHEMBL13259243 | 0.67 | METAP2 (0.39) | RAB9AL3MBTL1GPBAR1ATM | |
| SCHEMBL10229734 | 0.66 | GPBAR1 (0.64) | GPBAR1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010093845-A1 | TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY | EXELIXIS, INC. (US) | 2010-08-19 | — | — | WO | disclosed |