Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 10/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6657713 | 0.81 | KMT2A (0.37) | KMT2APRSS1CYP2C19CYP2D6RECQL | |
| SCHEMBL30461744 | 0.78 | MAPT (0.44) | KMT2APRSS1CYP2C19CYP2D6RECQL | |
| SCHEMBL418892 | 0.78 | MAPT (0.44) | KMT2APRSS1CYP2C19CYP2D6RECQL | |
| SCHEMBL10099695 | 0.78 | SMN1; SMN2 (0.43) | KMT2ACYP2C19CYP2D6TSHRTDP1 | |
| SCHEMBL3897070 | 0.74 | ALDH1A1 (0.47) | KMT2ARECQLTDP1KDM4EGLA | |
| SCHEMBL20571668 | 0.74 | KDM4E (0.41) | KMT2ACYP2C19RECQLKDM4EALDH1A1 | |
| SCHEMBL6896833 | 0.73 | KMT2A (0.62) | KMT2ATSHRTDP1KDM4EALDH1A1 | |
| SCHEMBL30128490 | 0.72 | KDM4E (0.49) | KMT2APRSS1CYP2C19CYP2D6RECQL | |
| SCHEMBL7375160 | 0.72 | KDM4E (0.49) | KMT2APRSS1CYP2C19CYP2D6RECQL | |
| SCHEMBL13259052 | 0.71 | MAPT (0.54) | KMT2ATSHRTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010093425-A1 | HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF | SEPRACOR INC. (US) | 2010-08-19 | — | — | WO | disclosed |