Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17155155 | 0.78 | ERN1 (0.34) | ERN1HPGDTSHRHTR2ASLC6A4 | |
| SCHEMBL17429171 | 0.75 | ERN1 (0.53) | ERN1HPGDTSHRHTR2ASLC6A4 | |
| SCHEMBL9176653 | 0.72 | AHR (0.47) | HPGDABL1ABCB1BCRFBP1 | |
| SCHEMBL9773322 | 0.72 | HSD17B10 (0.45) | KCNH2FBP1IDO1 | |
| SCHEMBL16955178 | 0.70 | ERN1 (0.38) | ERN1HPGDTSHRHTR2ASLC6A4 | |
| SCHEMBL16958040 | 0.70 | ERN1 (0.42) | ERN1HPGDTSHRHTR2ASLC6A4 | |
| SCHEMBL16724088 | 0.66 | PYCR1 (0.40) | ERN1HPGDTSHRTDP1ALDH1A1 | |
| SCHEMBL47975 | 0.65 | IDO1 (0.58) | TDP1HTTIDO1MAPK1 | |
| SCHEMBL5535067 | 0.65 | TDP1 (0.44) | ERN1HPGDTSHRTDP1MEN1 | |
| SCHEMBL19260210 | 0.65 | THRA (0.40) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7754728-B2 | Adenine compound and use thereof | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2010-07-13 | — | — | US | disclosed |