Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | HBB | P68871 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALPG | P10696 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10128969 | 0.78 | CYP19A1 (0.47) | APPMAPTMEN1KMT2ANPC1 | |
| SCHEMBL14401242 | 0.78 | NFE2L2 (0.44) | APPTXNRD1PTGS1NQO2 | |
| SCHEMBL5499439 | 0.78 | MAOB (0.38) | RELAMEN1KMT2A | |
| SCHEMBL22268556 | 0.78 | MAOB (0.38) | RELAMEN1KMT2A | |
| SCHEMBL14215914 | 0.77 | APP (0.47) | APPMAT2AKCNH2 | |
| SCHEMBL13264676 | 0.75 | RELA (0.50) | RELAAPPMAPTMEN1KMT2A | |
| SCHEMBL22333986 | 0.75 | MAPT (0.38) | MAPTMEN1KMT2ASMN1; SMN2CASP1 | |
| SCHEMBL1714446 | 0.74 | RELA (0.81) | RELAAPPMAPTMEN1KMT2A | |
| SCHEMBL13467434 | 0.74 | RELA (0.81) | RELAAPPMAPTMEN1KMT2A | |
| SCHEMBL7915381 | 0.74 | RELA (0.81) | RELAAPPMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7759502-B2 | Useful for inhibiting the aggregation of amyloid protein to form amyloid deposit | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-07-20 | — | — | US | disclosed |
| US-7250525-B2 | Stilbene derivatives and their use for binding and imaging amyloid plaques | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-07-31 | — | — | US | disclosed |