Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC4 | O15439 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 5/20 | 0.37 |
| ▸ | PPARD | Q03181 | 5/20 | 0.37 |
| ▸ | PPARA | Q07869 | 5/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TLR2 | O60603 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3440764 | 0.98 | ABCC4 (0.43) | ABCC4MAPTLMNATSHRNFKB1 | |
| SCHEMBL20564134 | 0.96 | ABCC4 (0.47) | ABCC4MAPTLMNATSHRNFKB1 | |
| SCHEMBL4157165 | 0.94 | ABCC4 (0.50) | ABCC4MAPTLMNATSHRNFKB1 | |
| SCHEMBL2783596 | 0.94 | ABCC4 (0.50) | ABCC4MAPTLMNATSHRNFKB1 | |
| SCHEMBL4166126 | 0.94 | ABCC4 (0.50) | ABCC4MAPTLMNATSHRNFKB1 | |
| SCHEMBL3440807 | 0.94 | ABCC4 (0.50) | ABCC4MAPTLMNATSHRNFKB1 | |
| SCHEMBL1907123 | 0.85 | MEN1 (0.39) | ABCC4MAPTLMNATSHRNFKB1 | |
| Acetonitrile SCHEMBL10783265 | 0.81 | ABCC4 (0.35) | ABCC4MAPT | |
| SCHEMBL10600265 | 0.75 | CES2 (0.38) | TSHRSLC22A6GPR84FFAR1FFAR4 | |
| SCHEMBL31571624 | 0.75 | TSHR (0.35) | TSHRSLC22A6GPR84FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8057574-B2 | Membrane post treatment | SIEMENS INDUSTRY, INC. (US) | 2011-11-15 | — | — | US | disclosed |