Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CCKBR | P32239 | 2/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | F12 | P00748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5800011 | 0.85 | ALDH1A1 (0.57) | ALDH1A1KCNH2PRMT5WDR77F2 | |
| SCHEMBL3749720 | 0.85 | ALDH1A1 (0.57) | ALDH1A1KCNH2PRMT5WDR77F2 | |
| SCHEMBL7944576 | 0.84 | KCNH2 (0.45) | ALDH1A1KCNH2PRMT5WDR77F2 | |
| SCHEMBL24651223 | 0.84 | KCNH2 (0.42) | ALDH1A1KCNH2PRMT5WDR77F2 | |
| Hydrochloric Acid SCHEMBL28797396 | 0.84 | ALDH1A1 (0.56) | ALDH1A1KCNH2PRMT5WDR77F2 | |
| Hydrochloric Acid SCHEMBL28270652 | 0.84 | ALDH1A1 (0.56) | ALDH1A1KCNH2PRMT5WDR77F2 | |
| SCHEMBL27862075 | 0.83 | ALDH1A1 (0.46) | ALDH1A1KCNH2PRMT5WDR77F2 | |
| SCHEMBL859610 | 0.80 | KCNH2 (0.44) | ALDH1A1KCNH2PRMT5WDR77F2 | |
| SCHEMBL29892593 | 0.80 | KCNH2 (0.44) | ALDH1A1KCNH2PRMT5WDR77F2 | |
| Hydrochloric Acid SCHEMBL29893284 | 0.79 | KCNH2 (0.43) | ALDH1A1KCNH2PRMT5WDR77F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7759380-B2 | Substituted pyrrolines as kinase inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2010-07-20 | — | — | US | disclosed |
| US-7329657-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-02-12 | — | — | US | disclosed |
| US-20070213386-A1 | Substituted pyrrolines as kinase inhibitors | ZHANG HAN-CHENG | 2007-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213386-A1 | Substituted pyrrolines as kinase inhibitors | PRKDC, MAP2K2, TTK | ALDH1A1 3937/4885KCNH2 3970/4885PRMT5 646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.