Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 18/20 | 0.57 |
| ▸ | GCK | P35557 | 2/20 | 0.47 |
| ▸ | GCKR | Q14397 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2901335 | 0.84 | HSD11B1 (0.54) | HSD11B1 | |
| SCHEMBL2904786 | 0.83 | HSD11B1 (0.58) | HSD11B1GCKGCKR | |
| SCHEMBL2901980 | 0.82 | HSD11B1 (0.52) | HSD11B1GCKGCKR | |
| SCHEMBL2907402 | 0.82 | HSD11B1 (0.52) | HSD11B1GCKGCKR | |
| SCHEMBL2907385 | 0.80 | HSD11B1 (0.56) | HSD11B1GCKGCKR | |
| SCHEMBL2907239 | 0.75 | USP2 (0.52) | HSD11B1GCKGCKR | |
| SCHEMBL2902011 | 0.72 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL2902958 | 0.72 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL2902014 | 0.72 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL2904352 | 0.72 | HSD11B1 (0.61) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7754890-B2 | Arylsulfones and uses related thereto | AMGEN INC. (US) | 2010-07-13 | — | — | US | disclosed |
| US-20080269283-A1 | ARYLSULFONES AND USES RELATED THERETO | AMGEN INC. | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269283-A1 | ARYLSULFONES AND USES RELATED THERETO | ARSA, SULT2A1, UGT2B7 | HSD11B1 108/4885GCK 544/4885GCKR 512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.