Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.54 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.50 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.50 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.50 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13984667 | 0.97 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPK1KMT2AHIF1AEPAS1 | |
| SCHEMBL13266877 | 0.97 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPK1KMT2AHIF1AEPAS1 | |
| SCHEMBL13984746 | 0.92 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPK1KMT2AHIF1AEPAS1 | |
| SCHEMBL13266891 | 0.92 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPK1KMT2AHIF1AEPAS1 | |
| SCHEMBL3002329 | 0.91 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPK1KMT2AHIF1AEPAS1 | |
| SCHEMBL13266873 | 0.89 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPK1KMT2AHIF1AEPAS1 | |
| SCHEMBL3020468 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPK1KMT2AHIF1AEPAS1 | |
| SCHEMBL3020471 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPK1KMT2AHIF1AEPAS1 | |
| SCHEMBL13266949 | 0.87 | KDM4E (0.54) | SMN1; SMN2MAPK1KMT2AHIF1AEPAS1 | |
| SCHEMBL3016808 | 0.84 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPK1KMT2AHIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190766-A1 | ANTIBACTERIAL AGENTS | ACHAOGEN, INC. (US) | 2010-07-29 | — | — | US | disclosed |
| WO-2008154642-A2 | ANTIBACTERIAL AGENTS | ACHAOGEN, INC. (US) | 2008-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190766-A1 | ANTIBACTERIAL AGENTS | MRPL21, SI, ABCB11 | SMN1; SMN2 2202/4885MAPK1 2069/4885KMT2A 4779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.