Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 6/20 | 0.60 |
| ▸ | P2RY1 | P47900 | 4/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.60 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | SRC | P12931 | 2/20 | 0.60 |
| ▸ | DPP4 | P27487 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.60 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.60 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.60 |
| ▸ | GAPDH | P04406 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | STAT6 | P42226 | 1/20 | 0.60 |
| ▸ | PI4KA | P42356 | 1/20 | 0.60 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.60 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL62486 | 0.87 | ADORA1 (0.65) | ADORA1P2RY1ADORA2ASMN1; SMN2P2RY2 | |
| SCHEMBL622588 | 0.87 | ADORA1 (0.69) | ADORA1P2RY1ADORA2ASMN1; SMN2P2RY2 | |
| SCHEMBL932846 | 0.87 | ADORA1 (0.65) | ADORA1P2RY1ADORA2ASMN1; SMN2P2RY2 | |
| SCHEMBL13269131 | 0.85 | ADORA1 (0.62) | ADORA1P2RY1ADORA2ASMN1; SMN2P2RY2 | |
| SCHEMBL4541368 | 0.85 | ADORA1 (0.64) | ADORA1P2RY1ADORA2ASMN1; SMN2P2RY2 | |
| SCHEMBL13269088 | 0.85 | ADORA1 (0.62) | ADORA1P2RY1ADORA2ASMN1; SMN2P2RY2 | |
| SCHEMBL13269154 | 0.85 | PDE2A (0.66) | ADORA1P2RY1ADORA2ASMN1; SMN2P2RY2 | |
| SCHEMBL13269106 | 0.84 | ADORA1 (0.61) | ADORA1P2RY1ADORA2ASMN1; SMN2P2RY2 | |
| SCHEMBL16670667 | 0.84 | P2RY1 (0.58) | ADORA1P2RY1ADORA2ASMN1; SMN2P2RY2 | |
| SCHEMBL16671284 | 0.84 | ADORA1 (0.60) | ADORA1P2RY1ADORA2ASMN1; SMN2P2RY2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10301348-B2 | Compounds for use in prevention and treatment of neurodegenerative diseases and pain | ACADEMIA SINICA (TW) | 2019-05-28 | — | — | US | disclosed |
| US-10174033-B2 | N6-substituted adenosine derivatives and N6-substituted adenine derivatives and uses thereof | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2019-01-08 | — | — | US | disclosed |
| EP-3060566-B1 | COMPOUNDS FOR USE IN PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES AND PAIN | ACADEMIA SINICA (TW) | 2018-09-05 | — | — | EP | disclosed |
| US-20160264613-A1 | COMPOUNDS FOR USE IN PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES AND PAIN | ACADEMIA SINICA (TW) | 2016-09-15 | — | — | US | disclosed |
| US-20130045942-A1 | N6-SUBSTITUTED ADENOSINE DERIVATIVES AND N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2013-02-21 | — | — | US | disclosed |
| EP-2511283-A1 | N6-SUBSTITUTED ADENOSINE DERIVATIVES, N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2012-10-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160264613-A1 | COMPOUNDS FOR USE IN PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES AND PAIN | ADORA2A, ADORA3, ADORA2B | ADORA1 6/4885P2RY1 31/4885ADORA2A 1/4885 |
| US-10301348-B2 | Compounds for use in prevention and treatment of neurodegenerative diseases and pain | ADORA2A, ADORA3, ADORA2B | ADORA1 6/4885P2RY1 31/4885ADORA2A 1/4885 |
| US-10174033-B2 | N6-substituted adenosine derivatives and N6-substituted adenine derivatives and uses thereof | ADORA2A, ADORA3, ADORA1 | ADORA1 3/4885P2RY1 10/4885ADORA2A 1/4885 |
| US-20130045942-A1 | N6-SUBSTITUTED ADENOSINE DERIVATIVES AND N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF | ADORA2A, ADORA3, ADORA1 | ADORA1 3/4885P2RY1 10/4885ADORA2A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.