Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.68 |
| ▸ | EGFR | P00533 | 17/20 | 0.68 |
| ▸ | PDGFRB | P09619 | 16/20 | 0.68 |
| ▸ | PDGFRA | P16234 | 10/20 | 0.68 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.42 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.42 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.42 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.42 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.42 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19242504 | 0.87 | KDR (0.52) | KDREGFRPDGFRBPDGFRAPKM | |
| SCHEMBL22432432 | 0.83 | KDR (0.71) | KDREGFRPDGFRBPDGFRA | |
| SCHEMBL3124173 | 0.81 | KDR (1.00) | KDREGFRPDGFRBPDGFRA | |
| SCHEMBL17858425 | 0.78 | KDR (1.00) | KDREGFRPDGFRBPDGFRA | |
| SCHEMBL17837014 | 0.78 | KDR (1.00) | KDREGFRPDGFRBPDGFRA | |
| SCHEMBL17837008 | 0.78 | KDR (1.00) | KDREGFRPDGFRBPDGFRA | |
| SCHEMBL17837022 | 0.76 | KDR (1.00) | KDREGFRPDGFRBPDGFRA | |
| SCHEMBL17837015 | 0.76 | KDR (0.82) | KDREGFRPDGFRBPDGFRA | |
| SCHEMBL17837005 | 0.75 | KDR (1.00) | KDREGFRPDGFRBPDGFRA | |
| SCHEMBL17837028 | 0.75 | KDR (1.00) | KDREGFRPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11618758-B2 | Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2023-04-04 | — | — | US | disclosed |
| US-20210032266-A1 | Bicyclic and Tricyclic Pyrimidine Tyrosine Kinase Inhibitors with Antitubulin Activity and Methods of Treating A Patient | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2021-02-04 | — | — | US | disclosed |
| US-10844075-B2 | Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2020-11-24 | — | — | US | disclosed |
| US-10385064-B2 | Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2019-08-20 | — | — | US | disclosed |
| US-20180105536-A1 | BICYCLIC AND TRICYCLIC PYRIMIDINE TYROSINE KINASE INHIBITORS WITH ANTITUBULIN ACTIVITY AND METHODS OF TREATING A PATIENT | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2018-04-19 | — | — | US | disclosed |
| EP-2670244-B1 | BICYCLIC AND TRICYCLIC PYRIMIDINE TYROSINE KINASE INHIBITORS WITH ANTITUBULIN ACTIVITY AND METHODS OF TREATING A PATIENT | UNIV HOLY GHOST DUQUESNE (US) | 2018-04-11 | — | — | EP | disclosed |
| US-9732090-B2 | Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient | DUQUESNE UNIVERSITY OF THE HOLY GHOST (US) | 2017-08-15 | — | — | US | disclosed |
| US-20160009731-A1 | Bicyclic and Tricyclic Pyrimidine Tyrosine Kinase Inhibitors with Antitubulin Activity and Methods of Treating a Patient | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2016-01-14 | — | — | US | disclosed |
| US-9139590-B2 | Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2015-09-22 | — | — | US | disclosed |
| US-20120264768-A1 | BICYCLIC AND TRICYCLIC PYRIMIDINE TYROSINE KINASE INHIBITORS WITH ANTITUBULIN ACTIVITY AND METHODS OF TREATING A PATIENT | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2012-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210032266-A1 | Bicyclic and Tricyclic Pyrimidine Tyrosine Kinase Inhibitors with Antitubulin Activity and Methods of Treating A Patient | TK1, UACA, DSTYK | KDR 32/4885EGFR 9/4885PDGFRB 283/4885 |
| US-11618758-B2 | Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient | TK1, UACA, DSTYK | KDR 32/4885EGFR 9/4885PDGFRB 283/4885 |
| US-20180105536-A1 | BICYCLIC AND TRICYCLIC PYRIMIDINE TYROSINE KINASE INHIBITORS WITH ANTITUBULIN ACTIVITY AND METHODS OF TREATING A PATIENT | TK1, UACA, DSTYK | KDR 32/4885EGFR 9/4885PDGFRB 283/4885 |
| US-20120264768-A1 | BICYCLIC AND TRICYCLIC PYRIMIDINE TYROSINE KINASE INHIBITORS WITH ANTITUBULIN ACTIVITY AND METHODS OF TREATING A PATIENT | TK1, UACA, DSTYK | KDR 32/4885EGFR 9/4885PDGFRB 283/4885 |
| US-10385064-B2 | Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient | TK1, UACA, DSTYK | KDR 32/4885EGFR 9/4885PDGFRB 283/4885 |
| US-10844075-B2 | Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient | TK1, UACA, DSTYK | KDR 32/4885EGFR 9/4885PDGFRB 283/4885 |
| US-20160009731-A1 | Bicyclic and Tricyclic Pyrimidine Tyrosine Kinase Inhibitors with Antitubulin Activity and Methods of Treating a Patient | TK1, UACA, DSTYK | KDR 32/4885EGFR 9/4885PDGFRB 283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.