Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 17/20 | 0.47 |
| ▸ | S1PR2 | O95136 | 16/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 16/20 | 0.47 |
| ▸ | LPAR2 | Q9HBW0 | 13/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.45 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.45 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13276068 | 1.00 | S1PR3 (0.47) | S1PR3S1PR2S1PR1LPAR2S1PR4 | |
| SCHEMBL13276291 | 0.89 | S1PR3 (0.38) | S1PR3S1PR2S1PR1LPAR2S1PR4 | |
| SCHEMBL13276248 | 0.88 | GLO1 (0.39) | S1PR3S1PR2S1PR1LPAR2GLO1 | |
| SCHEMBL13276400 | 0.88 | S1PR3 (0.43) | S1PR3S1PR2S1PR1LPAR2S1PR4 | |
| SCHEMBL13276325 | 0.88 | S1PR3 (0.60) | S1PR3S1PR2S1PR1LPAR2S1PR4 | |
| SCHEMBL13276059 | 0.88 | S1PR3 (0.60) | S1PR3S1PR2S1PR1LPAR2S1PR4 | |
| SCHEMBL13276093 | 0.88 | S1PR3 (0.42) | S1PR3S1PR2S1PR1LPAR2S1PR4 | |
| SCHEMBL13276350 | 0.86 | S1PR1 (0.52) | S1PR3S1PR2S1PR1LPAR2S1PR4 | |
| SCHEMBL13276303 | 0.86 | DGAT2 (0.38) | S1PR3S1PR2S1PR1LPAR2S1PR4 | |
| SCHEMBL13277411 | 0.85 | S1PR1 (0.55) | S1PR3S1PR2S1PR1LPAR2S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697212-B1 | PHENYL BICYCLIC METHYL AMINE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | ALLERGAN INC (US) | 2015-09-09 | — | — | EP | claimed |
| EP-2697212-A1 | PHENYL BICYCLIC METHYL AMINE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | Allergan, Inc. (US) | 2014-02-19 | — | — | EP | claimed |
| US-8653050-B2 | Phenyl bicyclic methyl amine derivatives as sphingosine-1 phosphate receptors modulators | ALLERGAN, INC. (US) | 2014-02-18 | — | — | US | claimed |
| US-20130338108-A1 | PHENYL BICYCLIC METHYL AMINE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | ALLERGAN, INC. | 2013-12-19 | — | — | US | claimed |
| US-8541582-B2 | Phenyl bicyclic methyl amine derivatives as sphingosine-1 phosphate receptors modulators | ALLERGAN, INC. (US) | 2013-09-24 | — | — | US | claimed |
| US-20120264716-A1 | PHENYL BICYCLIC METHYL AMINE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | ALLERGAN, INC. | 2012-10-18 | — | — | US | claimed |
| WO-2012142288-A1 | PHENYL BICYCLIC METHYL AMINE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | ALLERGAN, INC. (US) | 2012-10-18 | — | — | WO | claimed |
| EP-2697212-B1 | PHENYL BICYCLIC METHYL AMINE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | ALLERGAN INC (US) | 2015-09-09 | — | — | EP | disclosed |
| EP-2697212-A1 | PHENYL BICYCLIC METHYL AMINE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | Allergan, Inc. (US) | 2014-02-19 | — | — | EP | disclosed |
| US-8653050-B2 | Phenyl bicyclic methyl amine derivatives as sphingosine-1 phosphate receptors modulators | ALLERGAN, INC. (US) | 2014-02-18 | — | — | US | disclosed |
| US-20130338108-A1 | PHENYL BICYCLIC METHYL AMINE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | ALLERGAN, INC. | 2013-12-19 | — | — | US | disclosed |
| US-8541582-B2 | Phenyl bicyclic methyl amine derivatives as sphingosine-1 phosphate receptors modulators | ALLERGAN, INC. (US) | 2013-09-24 | — | — | US | disclosed |
| US-20120264716-A1 | PHENYL BICYCLIC METHYL AMINE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | ALLERGAN, INC. | 2012-10-18 | — | — | US | disclosed |
| WO-2012142288-A1 | PHENYL BICYCLIC METHYL AMINE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | ALLERGAN, INC. (US) | 2012-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130338108-A1 | PHENYL BICYCLIC METHYL AMINE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | S1PR1, S1PR3, S1PR2 | S1PR3 2/4885S1PR2 3/4885S1PR1 1/4885 |
| US-20120264716-A1 | PHENYL BICYCLIC METHYL AMINE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | S1PR1, S1PR3, S1PR2 | S1PR3 2/4885S1PR2 3/4885S1PR1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.