Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 9/20 | 0.55 |
| ▸ | MEN1 | O00255 | 7/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13278326 | 1.00 | ALDH1A1 (0.57) | ALDH1A1PKMGPR55MAPTMEN1 | |
| SCHEMBL4098988 | 0.87 | ALDH1A1 (0.62) | ALDH1A1PKMGPR55MAPTMEN1 | |
| SCHEMBL13741911 | 0.87 | ALDH1A1 (0.62) | ALDH1A1PKMGPR55MAPTMEN1 | |
| SCHEMBL4098990 | 0.87 | ALDH1A1 (0.62) | ALDH1A1PKMGPR55MAPTMEN1 | |
| SCHEMBL9365082 | 0.82 | PKM (0.67) | ALDH1A1PKMGPR55MAPTMEN1 | |
| SCHEMBL9365089 | 0.82 | PKM (0.67) | ALDH1A1PKMGPR55MAPTMEN1 | |
| SCHEMBL13090694 | 0.79 | PKM (0.62) | ALDH1A1PKMGPR55MAPTMEN1 | |
| SCHEMBL8541606 | 0.79 | EGFR (0.65) | ALDH1A1PKMGPR55MAPTMEN1 | |
| SCHEMBL21457335 | 0.78 | MAPT (0.70) | ALDH1A1PKMGPR55MAPTMEN1 | |
| SCHEMBL5255426 | 0.78 | MAPT (0.70) | ALDH1A1PKMGPR55MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9085575-B2 | Tri- and tetracyclic pyrazolo[3,4-B]pyridine compounds as antineoplastic agent | PIERRE FABRE MEDICAMENT (FR) | 2015-07-21 | — | — | US | disclosed |
| EP-2697222-A1 | TRI- AND TETRACYCLIC PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS AS ANTINEOPLASTIC AGENT | Pierre Fabre Medicament (FR) | 2014-02-19 | — | — | EP | disclosed |
| US-20140031362-A1 | TRI - AND TETRACYCLIC PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS AS ANTINEOPLASTIC AGENT | PIERRE FABRE MEDICAMENT (FR) | 2014-01-30 | — | — | US | disclosed |
| WO-2012140114-A1 | TRI- AND TETRACYCLIC PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS AS ANTINEOPLASTIC AGENT | PIERRE FABRE MEDICAMENT (FR) | 2012-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031362-A1 | TRI - AND TETRACYCLIC PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS AS ANTINEOPLASTIC AGENT | TPMT, TYMP, PAICS | ALDH1A1 1022/4885PKM 759/4885GPR55 2142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.