Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | PREP | P48147 | 3/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.35 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.35 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12069832 | 0.81 | EPHX2 (0.51) | EPHX2CCR5KCNH2CHRM4GPR119 | |
| SCHEMBL15931983 | 0.76 | ALDH1A1 (0.44) | EPHX2HCRTR1HCRTR2CCR5KCNH2 | |
| SCHEMBL19472916 | 0.75 | ALDH1A1 (0.51) | PREP | |
| SCHEMBL10518999 | 0.75 | EPHX2 (0.36) | CHRM2CHRM1CHRM3EPHX2HCRTR1 | |
| SCHEMBL15932009 | 0.74 | PTPN1 (0.37) | CHRM2CHRM1CHRM3EPHX2HCRTR1 | |
| SCHEMBL1128582 | 0.71 | EPHX2 (0.42) | EPHX2HCRTR1HCRTR2CCR5KCNH2 | |
| SCHEMBL1128579 | 0.71 | EPHX2 (0.42) | EPHX2HCRTR1HCRTR2CCR5KCNH2 | |
| SCHEMBL4355370 | 0.71 | EPHX2 (0.42) | EPHX2HCRTR1HCRTR2CCR5KCNH2 | |
| SCHEMBL1128755 | 0.70 | ALDH1A1 (0.51) | EPHX2HCRTR1HCRTR2CCR5KCNH2 | |
| SCHEMBL5004068 | 0.70 | CCR5 (0.45) | EPHX2HCRTR1HCRTR2CCR5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010075273-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION (US) | 2010-07-01 | — | — | WO | disclosed |