Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PROKR2 | Q8NFJ6 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL564165 | 0.91 | PROKR2 (0.48) | TSHRMAPTPROKR2MEN1KMT2A | |
| SCHEMBL565270 | 0.87 | TSHR (0.50) | TSHRMAPTMEN1KMT2AGAA | |
| SCHEMBL13284771 | 0.86 | PROKR2 (0.46) | TSHRMAPTPROKR2GAAALDH1A1 | |
| SCHEMBL13284391 | 0.78 | PROKR2 (0.44) | MAPTPROKR2MEN1KMT2AALDH1A1 | |
| SCHEMBL565457 | 0.78 | PROKR2 (0.49) | MAPTPROKR2ALDH1A1HPGDHDAC1 | |
| SCHEMBL565624 | 0.77 | PROKR2 (0.56) | TSHRMAPTPROKR2MEN1KMT2A | |
| SCHEMBL564998 | 0.76 | PROKR2 (0.52) | TSHRPROKR2GAAALDH1A1HPGD | |
| SCHEMBL564997 | 0.75 | PROKR2 (0.51) | PROKR2ALDH1A1HDAC1 | |
| SCHEMBL13284091 | 0.74 | PROKR2 (0.46) | TSHRPROKR2MEN1KMT2AGAA | |
| SCHEMBL10107603 | 0.72 | TSHR (0.53) | TSHRMAPTPROKR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077976-A2 | PROKINETICIN RECEPTOR ANTAGONISTS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-07-08 | — | — | WO | disclosed |