Sugi Predict

Sugi Predict / Compounds / SCHEMBL565457

SCHEMBL565457

SCHEMBL565457

CC(C)CN(Cc1cc(Cl)c2c(c1)OCCCO2)C(=O)CCCCc1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PROKR2 Q8NFJ6 5/20 0.49
▸ ALDH1A1 P00352 3/20 0.43
▸ SMN1; SMN2 Q16637 4/20 0.41
▸ TDP1 Q9NUW8 2/20 0.41
▸ KLF5 Q13887 2/20 0.41
▸ LMNA P02545 1/20 0.41
▸ TP53 P04637 1/20 0.41
▸ MAPT P10636 1/20 0.41
▸ L3MBTL1 Q9Y468 1/20 0.41
▸ ALOX5 P09917 2/20 0.40
▸ NPC1 O15118 5/20 0.39
▸ RAB9A P51151 4/20 0.39
▸ HPGD P15428 2/20 0.39
▸ CASP3 P42574 1/20 0.39
▸ SENP8 Q96LD8 1/20 0.39
▸ SENP7 Q9BQF6 1/20 0.39
▸ SENP6 Q9GZR1 1/20 0.39
▸ NFKB1 P19838 1/20 0.37
▸ NFKB2 Q00653 1/20 0.37
▸ RELA Q04206 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL564165 0.87 PROKR2 (0.48) PROKR2ALDH1A1MAPTNPC1RAB9A
SCHEMBL564998 0.86 PROKR2 (0.52) PROKR2ALDH1A1SMN1; SMN2KLF5NPC1
SCHEMBL564997 0.86 PROKR2 (0.51) PROKR2ALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL565921 0.83 PROKR2 (0.53) PROKR2ALDH1A1SMN1; SMN2TDP1KLF5
SCHEMBL565231 0.83 PROKR2 (0.53) PROKR2ALDH1A1SMN1; SMN2TDP1KLF5
SCHEMBL10106665 0.83 PROKR2 (0.53) PROKR2ALDH1A1SMN1; SMN2TDP1KLF5
SCHEMBL564260 0.81 PROKR2 (0.51) PROKR2ALDH1A1LMNAMAPT
SCHEMBL564468 0.81 PROKR2 (0.51) PROKR2ALDH1A1LMNAMAPT
SCHEMBL10119874 0.80 PROKR2 (0.56) PROKR2ALDH1A1SMN1; SMN2MAPTNPC1
SCHEMBL565858 0.80 PROKR2 (0.56) PROKR2ALDH1A1SMN1; SMN2MAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8722896-B2 Prokineticin receptor antagonists and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-05-13 — — US disclosed
US-8722896-B2 Prokineticin receptor antagonists and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-05-13 — — US disclosed
US-8722896-B2 Prokineticin receptor antagonists and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-05-13 — — US disclosed
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-09 — — US disclosed
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-09 — — US disclosed
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-02-09 — — US disclosed
WO-2010077976-A2 PROKINETICIN RECEPTOR ANTAGONISTS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2010-07-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120035149-A1 Prokineticin Receptor Antagonists And Uses Thereof PROKR2, PROKR1, GIPR PROKR2 1/4885ALDH1A1 4725/4885SMN1; SMN2 2106/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.