Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.38 |
| ▸ | FEN1 | P39748 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | ESRRA | P11474 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14080786 | 1.00 | ALOX5AP (0.38) | ALOX5APFEN1ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL3692986 | 0.88 | AR (0.37) | ALOX5APFEN1ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL3692984 | 0.88 | AR (0.37) | ALOX5APFEN1ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL3689680 | 0.86 | KDM4E (0.44) | ALOX5APFEN1ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL20155520 | 0.79 | KEAP1 (0.46) | ALOX5APFEN1ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL4597701 | 0.79 | KDM4E (0.50) | ALDH1A1KDM4EL3MBTL1MAPTLMNA | |
| SCHEMBL17354630 | 0.76 | AR (0.44) | ALOX5APFEN1ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL8917573 | 0.76 | HSPB1 (0.53) | ALDH1A1KDM4EL3MBTL1MAPTLMNA | |
| SCHEMBL12594180 | 0.74 | KEAP1 (0.52) | ALOX5APFEN1ALDH1A1KDM4EAR | |
| SCHEMBL3887260 | 0.73 | KDM4E (0.43) | ALOX5APFEN1ALDH1A1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2208727-A1 | Diaryl ethers as opioid receptor antagonist | Eli Lilly & Company (US) | 2010-07-21 | — | — | EP | disclosed |
| US-7414132-B2 | Opioid receptor antagonists | ELI LILLY AND COMPANY (US) | 2008-08-19 | — | — | US | disclosed |
| EP-1562595-B1 | DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-05-21 | — | — | EP | disclosed |