Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | PRKACA | P17612 | 2/20 | 0.47 |
| ▸ | GSK3A | P49840 | 2/20 | 0.47 |
| ▸ | PRKX | P51817 | 2/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13285983 | 0.92 | MMP13 (0.49) | MMP13GAAROCK2ROCK1CYP3A4 | |
| SCHEMBL792267 | 0.89 | CYP3A4 (0.57) | MMP13GAAROCK2ROCK1CYP3A4 | |
| SCHEMBL13285990 | 0.81 | RAB9A (0.50) | ROCK2ROCK1CYP3A4CYP2C9MAPK1 | |
| SCHEMBL10283543 | 0.81 | CYP3A4 (0.57) | MMP13GAAROCK2ROCK1CYP3A4 | |
| SCHEMBL13286253 | 0.73 | CYP3A4 (0.38) | ROCK2CYP3A4CLK4CYP2D6MAPK1 | |
| SCHEMBL13286177 | 0.73 | HPGD (0.44) | MMP13CYP2D6CYP2C9SMN1; SMN2MAPK14 | |
| SCHEMBL13285970 | 0.72 | MAPK14 (0.45) | GAAROCK2SMN1; SMN2MAPK14ALDH1A1 | |
| SCHEMBL30828595 | 0.72 | MMP13 (0.88) | MMP13GAAROCK2ROCK1CYP3A4 | |
| SCHEMBL13947076 | 0.71 | NR1H4 (0.71) | MMP13GAACYP3A4LMNAMAPK1 | |
| SCHEMBL13286176 | 0.71 | PLK1 (0.39) | ROCK2ROCK1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2206715-A1 | Fused heterotetracyclic compounds and use thereof as hcv polymerase inhibitor | Japan Tobacco, Inc. (JP) | 2010-07-14 | — | — | EP | disclosed |