Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 5/20 | 0.47 |
| ▸ | GSK3B | P49841 | 5/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13288665 | 0.93 | CDK2 (0.46) | CDK2GSK3BACKR3MAPT | |
| SCHEMBL14581256 | 0.92 | AURKA (0.45) | CDK2GSK3BAURKAAURKBMEN1 | |
| SCHEMBL13119679 | 0.92 | CDK2 (0.58) | CDK2GSK3BAURKAAURKB | |
| SCHEMBL13289326 | 0.92 | CDK2 (0.47) | CDK2GSK3BAURKAAURKBMEN1 | |
| SCHEMBL13288642 | 0.90 | CDK2 (0.49) | CDK2GSK3BRETKDR | |
| SCHEMBL13289323 | 0.89 | CDK2 (0.48) | CDK2GSK3BAURKAAURKBMEN1 | |
| SCHEMBL13288878 | 0.88 | CDK2 (0.49) | CDK2GSK3BMEN1NPC1RAB9A | |
| SCHEMBL13289130 | 0.88 | RET (0.48) | CDK2GSK3BAURKAAURKBMEN1 | |
| SCHEMBL13288729 | 0.86 | CDK2 (0.51) | CDK2GSK3BMEN1KMT2A | |
| SCHEMBL13288880 | 0.86 | CDK2 (0.44) | CDK2GSK3BABL1RETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |