Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 4/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 5/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.45 |
| ▸ | SENP5 | Q96HI0 | 1/20 | 0.44 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.44 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13119674 | 0.92 | CDK2 (0.58) | RETKDRCDK2GSK3BAURKA | |
| SCHEMBL13289534 | 0.92 | RET (0.48) | RETKDRCDK2GSK3BCYP1A2 | |
| SCHEMBL13288642 | 0.90 | CDK2 (0.49) | RETKDRCDK2GSK3BSENP1 | |
| SCHEMBL13288878 | 0.90 | CDK2 (0.49) | CDK2GSK3BSENP5SENP2SENP1 | |
| SCHEMBL13288889 | 0.89 | GSK3B (0.47) | RETKDRCDK2GSK3BSENP5 | |
| SCHEMBL13289304 | 0.89 | CDK2 (0.48) | RETKDRCDK2GSK3BAURKA | |
| SCHEMBL13289345 | 0.89 | GSK3B (0.47) | RETKDRCDK2GSK3BAURKA | |
| SCHEMBL13288663 | 0.88 | CDK2 (0.47) | RETKDRCDK2GSK3BAURKA | |
| SCHEMBL13288759 | 0.87 | CDK2 (0.46) | RETKDRCDK2GSK3BSENP5 | |
| SCHEMBL13288729 | 0.86 | CDK2 (0.51) | CDK2GSK3BSENP5SENP2SENP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |