Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 5/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13288663 | 0.93 | CDK2 (0.47) | CDK2GSK3BMAPTACKR3 | |
| SCHEMBL13119677 | 0.92 | CDK2 (0.57) | CDK2GSK3BRORC | |
| SCHEMBL13289323 | 0.92 | CDK2 (0.48) | CDK2GSK3BROCK2MAPTEPAS1 | |
| SCHEMBL13288880 | 0.88 | CDK2 (0.44) | CDK2GSK3BROCK2BRAFMAPT | |
| SCHEMBL13288759 | 0.88 | CDK2 (0.46) | CDK2GSK3BMAPT | |
| SCHEMBL13289326 | 0.88 | CDK2 (0.47) | CDK2GSK3BROCK2MAPT | |
| SCHEMBL13288878 | 0.88 | CDK2 (0.49) | CDK2GSK3BACKR3 | |
| SCHEMBL13288889 | 0.87 | GSK3B (0.47) | CDK2GSK3BMAPT | |
| SCHEMBL13288642 | 0.86 | CDK2 (0.49) | CDK2GSK3B | |
| SCHEMBL13288729 | 0.86 | CDK2 (0.51) | CDK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |