Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.44 |
| ▸ | CDK2 | P24941 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | VEGFA | P15692 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.34 |
| ▸ | PTPRC | P08575 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13288875 | 0.95 | GSK3B (0.46) | GSK3BCDK2ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL13120097 | 0.90 | GSK3B (0.58) | GSK3BCDK2ALDH1A1 | |
| SCHEMBL13120020 | 0.88 | GSK3B (0.58) | GSK3BCDK2ALDH1A1 | |
| SCHEMBL13288684 | 0.84 | CDK2 (0.44) | GSK3BCDK2ABL1 | |
| SCHEMBL13120231 | 0.84 | GSK3B (0.60) | GSK3BCDK2ALDH1A1 | |
| SCHEMBL13288948 | 0.84 | BRD4 (0.45) | GSK3BCDK2ALDH1A1MEN1KMT2A | |
| SCHEMBL13289182 | 0.84 | CDK2 (0.46) | GSK3BCDK2ALDH1A1MEN1KMT2A | |
| SCHEMBL13288732 | 0.84 | CDK2 (0.43) | GSK3BCDK2ALDH1A1RXFP1KMT2A | |
| SCHEMBL13288661 | 0.84 | CDK2 (0.48) | GSK3BCDK2ABL1MEN1KMT2A | |
| SCHEMBL12954170 | 0.83 | CDK2 (0.51) | GSK3BCDK2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |