Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 8/20 | 0.45 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14545834 | 0.95 | GSK3B (0.44) | BRD4GSK3BCDK2L3MBTL1ALDH1A1 | |
| SCHEMBL13120107 | 0.90 | GSK3B (0.55) | BRD4GSK3BCDK2NAMPTL3MBTL1 | |
| SCHEMBL13120028 | 0.89 | GSK3B (0.55) | BRD4GSK3BCDK2L3MBTL1ALDH1A1 | |
| SCHEMBL13288648 | 0.88 | CDK2 (0.51) | GSK3BCDK2HDAC1ALDH1A1MEN1 | |
| SCHEMBL13289182 | 0.85 | CDK2 (0.46) | BRD4GSK3BCDK2HDAC1ALDH1A1 | |
| SCHEMBL13289170 | 0.85 | KMT2A (0.45) | BRD4GSK3BCDK2HDAC3HDAC1 | |
| SCHEMBL14545832 | 0.85 | CDK2 (0.48) | BRD4GSK3BCDK2L3MBTL1ALDH1A1 | |
| SCHEMBL13120243 | 0.85 | GSK3B (0.57) | GSK3BCDK2L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL13289360 | 0.84 | ALDH1A1 (0.46) | GSK3BCDK2HDAC3HDAC1L3MBTL1 | |
| SCHEMBL13288682 | 0.84 | GSK3B (0.44) | GSK3BCDK2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |