Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.46 |
| ▸ | GSK3B | P49841 | 4/20 | 0.44 |
| ▸ | ABL1 | P00519 | 10/20 | 0.44 |
| ▸ | VCP | P55072 | 1/20 | 0.38 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12954447 | 0.98 | CDK2 (0.46) | CDK2GSK3BABL1VCPSMYD2 | |
| SCHEMBL13288826 | 0.96 | CDK2 (0.44) | CDK2GSK3BABL1TSHR | |
| SCHEMBL13288867 | 0.94 | CDK2 (0.47) | CDK2GSK3BABL1VCPTSHR | |
| SCHEMBL13289218 | 0.92 | CDK2 (0.44) | CDK2GSK3BABL1SMYD2 | |
| SCHEMBL14613489 | 0.92 | GSK3B (0.39) | CDK2GSK3BABL1TSHR | |
| SCHEMBL13288670 | 0.91 | CDK2 (0.42) | CDK2GSK3BABL1 | |
| SCHEMBL14545262 | 0.90 | CDK2 (0.45) | CDK2GSK3BABL1TSHR | |
| SCHEMBL13120087 | 0.89 | CDK2 (0.59) | CDK2GSK3BABL1 | |
| SCHEMBL13288684 | 0.89 | CDK2 (0.44) | CDK2GSK3BABL1VCPSMYD2 | |
| SCHEMBL13288928 | 0.88 | PKM (0.43) | CDK2GSK3BTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |