Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.47 |
| ▸ | ABL1 | P00519 | 10/20 | 0.45 |
| ▸ | GSK3B | P49841 | 4/20 | 0.45 |
| ▸ | VCP | P55072 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14545262 | 0.95 | CDK2 (0.45) | CDK2ABL1GSK3BTSHR | |
| SCHEMBL12954447 | 0.94 | CDK2 (0.46) | CDK2ABL1GSK3BVCP | |
| SCHEMBL13288683 | 0.94 | CDK2 (0.46) | CDK2ABL1GSK3BVCPTSHR | |
| SCHEMBL13288877 | 0.92 | CDK2 (0.45) | CDK2ABL1GSK3B | |
| SCHEMBL13288826 | 0.91 | CDK2 (0.44) | CDK2ABL1GSK3BTSHR | |
| SCHEMBL13120202 | 0.89 | CDK2 (0.61) | CDK2ABL1GSK3B | |
| SCHEMBL13288970 | 0.88 | CDK2 (0.45) | CDK2ABL1GSK3BVCP | |
| SCHEMBL13289277 | 0.87 | CDK2 (0.42) | CDK2ABL1GSK3BVCP | |
| SCHEMBL14301237 | 0.87 | CDK2 (0.43) | CDK2GSK3B | |
| SCHEMBL13289218 | 0.87 | CDK2 (0.44) | CDK2ABL1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |