Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.40 |
| ▸ | CDK2 | P24941 | 5/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | KLK1 | P06870 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13120345 | 0.91 | GSK3B (0.52) | GSK3BCDK2ABCB1ABCG2KDM4E | |
| SCHEMBL13288758 | 0.89 | KDM4E (0.42) | GSK3BCDK2KDM4EMAPTMAPK1 | |
| SCHEMBL13288834 | 0.89 | GSK3B (0.42) | GSK3BCDK2KDM4EMAPTMAPK1 | |
| SCHEMBL13289307 | 0.88 | GSK3B (0.41) | GSK3BCDK2KDM4EMAPTMAPK1 | |
| SCHEMBL13288912 | 0.87 | GSK3B (0.43) | GSK3BCDK2KDM4EMAPTMAPK1 | |
| SCHEMBL13288809 | 0.86 | CDK2 (0.43) | GSK3BCDK2BRD4PDE2A | |
| SCHEMBL13288966 | 0.85 | GSK3B (0.40) | GSK3BCDK2KDM4EMAPTMAPK1 | |
| SCHEMBL13288933 | 0.85 | RAB9A (0.41) | GSK3BCDK2MAPTRAB9A | |
| SCHEMBL13289036 | 0.85 | ALDH1A1 (0.40) | GSK3BCDK2KDM4EMAPTMAPK1 | |
| SCHEMBL13288863 | 0.85 | CSNK2A1 (0.39) | GSK3BCDK2KDM4EMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |