Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 4/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13289235 | 0.92 | CDK2 (0.45) | CDK2BRD4GSK3BNAMPTHDAC3 | |
| SCHEMBL13289231 | 0.90 | DRD2 (0.46) | CDK2GSK3BHDAC3HDAC1 | |
| SCHEMBL13288868 | 0.90 | CDK2 (0.52) | CDK2BRD4GSK3BNAMPTHDAC3 | |
| SCHEMBL13289182 | 0.90 | CDK2 (0.46) | CDK2BRD4GSK3BHDAC1MEN1 | |
| SCHEMBL13288697 | 0.90 | NAMPT (0.45) | CDK2GSK3BNAMPTHDAC3HDAC1 | |
| SCHEMBL13120110 | 0.90 | CDK2 (0.58) | CDK2BRD4GSK3BNAMPTHDAC3 | |
| SCHEMBL13120031 | 0.89 | CDK2 (0.57) | CDK2BRD4GSK3BNAMPTMEN1 | |
| SCHEMBL13288809 | 0.87 | CDK2 (0.43) | CDK2BRD4GSK3BNAMPTHDAC3 | |
| SCHEMBL13288811 | 0.87 | CDK2 (0.44) | CDK2GSK3BNAMPTSMN1; SMN2 | |
| SCHEMBL13288680 | 0.85 | CDK2 (0.44) | CDK2GSK3BHDAC3HDAC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |