Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 4/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13288868 | 0.93 | CDK2 (0.52) | CDK2GSK3BBRD4HDAC3HDAC1 | |
| SCHEMBL13288952 | 0.92 | CDK2 (0.44) | CDK2KMT2AGSK3BBRD4HDAC3 | |
| SCHEMBL13288811 | 0.91 | CDK2 (0.44) | CDK2GSK3BDRD2DRD4DRD3 | |
| SCHEMBL13289231 | 0.91 | DRD2 (0.46) | CDK2GSK3BDRD2DRD4DRD3 | |
| SCHEMBL13120150 | 0.89 | CDK2 (0.58) | CDK2KMT2AGSK3BBRD4DRD2 | |
| SCHEMBL13289182 | 0.89 | CDK2 (0.46) | CDK2KMT2AGSK3BBRD4DRD3 | |
| SCHEMBL13289170 | 0.89 | KMT2A (0.45) | CDK2KMT2AGSK3BBRD4HDAC3 | |
| SCHEMBL13288809 | 0.88 | CDK2 (0.43) | CDK2GSK3BBRD4HDAC3HDAC1 | |
| SCHEMBL13288754 | 0.88 | CDK2 (0.45) | CDK2KMT2AGSK3BDRD2DRD4 | |
| SCHEMBL13120075 | 0.88 | CDK2 (0.58) | CDK2KMT2AGSK3BBRD4SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |