Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.47 |
| ▸ | CDK2 | P24941 | 4/20 | 0.47 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13288841 | 0.92 | GSK3B (0.47) | GSK3BCDK2MEN1KMT2AMAPT | |
| SCHEMBL13120102 | 0.89 | CDK2 (0.61) | GSK3BCDK2 | |
| SCHEMBL13120015 | 0.88 | CDK2 (0.61) | GSK3BCDK2 | |
| SCHEMBL14545258 | 0.88 | GSK3B (0.46) | GSK3BCDK2BRD4MEN1KMT2A | |
| SCHEMBL13288955 | 0.86 | GSK3B (0.45) | GSK3BCDK2MEN1KMT2AMAPT | |
| SCHEMBL13120167 | 0.84 | CDK2 (0.57) | GSK3BCDK2 | |
| SCHEMBL13305640 | 0.84 | CDK2 (0.54) | GSK3BCDK2MEN1KMT2AMAPT | |
| SCHEMBL13120234 | 0.84 | CDK2 (0.63) | GSK3BCDK2 | |
| SCHEMBL13120181 | 0.83 | CDK2 (0.58) | GSK3BCDK2MEN1KMT2AHPGD | |
| SCHEMBL14545879 | 0.83 | CDK2 (0.54) | GSK3BCDK2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |