Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 5/20 | 0.54 |
| ▸ | GSK3B | P49841 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13119541 | 0.90 | CDK2 (0.68) | CDK2GSK3BMEN1KMT2AALDH1A1 | |
| SCHEMBL14545901 | 0.88 | CDK2 (0.55) | CDK2GSK3BMEN1KMT2AKDM4E | |
| SCHEMBL13305611 | 0.88 | CDK2 (0.48) | CDK2GSK3BMEN1KMT2AALDH1A1 | |
| SCHEMBL13119594 | 0.86 | CDK2 (0.65) | CDK2GSK3B | |
| SCHEMBL14561495 | 0.84 | CDK2 (0.64) | CDK2GSK3BMEN1KMT2AALDH1A1 | |
| SCHEMBL13289193 | 0.83 | GSK3B (0.47) | CDK2GSK3BMEN1KMT2AALDH1A1 | |
| SCHEMBL13305406 | 0.83 | CDK2 (0.44) | CDK2GSK3BMEN1KMT2AKDM4E | |
| SCHEMBL13119592 | 0.83 | CDK2 (0.66) | CDK2GSK3B | |
| SCHEMBL13289337 | 0.83 | GSK3B (0.50) | CDK2GSK3BKDRMAPTPSD | |
| SCHEMBL13119580 | 0.83 | CDK2 (0.65) | CDK2GSK3BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |