Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.46 |
| ▸ | CDK2 | P24941 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13120088 | 0.90 | GSK3B (0.59) | GSK3BCDK2 | |
| SCHEMBL13120009 | 0.89 | GSK3B (0.59) | GSK3BCDK2 | |
| SCHEMBL13289193 | 0.88 | GSK3B (0.47) | GSK3BCDK2ALDH1A1FGFR1BRD4 | |
| SCHEMBL13288841 | 0.87 | GSK3B (0.47) | GSK3BCDK2ALDH1A1KDM4EMEN1 | |
| SCHEMBL13120220 | 0.85 | GSK3B (0.61) | GSK3BCDK2 | |
| SCHEMBL13288740 | 0.85 | GSK3B (0.46) | GSK3BCDK2ALDH1A1TP53 | |
| SCHEMBL13305020 | 0.82 | GSK3B (0.55) | GSK3BCDK2ALDH1A1KDM4EMEN1 | |
| SCHEMBL13289249 | 0.82 | GSK3B (0.46) | GSK3BCDK2ALDH1A1KDM4EMEN1 | |
| SCHEMBL13304619 | 0.82 | GSK3B (0.55) | GSK3BCDK2ALDH1A1FGFR1KDM4E | |
| SCHEMBL14301238 | 0.81 | KMT2A (0.40) | GSK3BALDH1A1KDM4EMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |